Histone Methylation

Histone methylation is a reversible process by which methyl groups are covalently added to histones. It plays a critical role in regulating gene expression, as it can alter the accessibility of DNA to the cellular machinery that reads and interprets it. Types of Histone Methylation There are several different types of histone methylation, including: Lysine Methylation Lysine methylation can occur at various positions on the hist...

Histone methyltransferases (HMTs) are enzymes that catalyze the transfer of methyl groups to histones. Methylation of histones can regulate the accessibility of DNA to the cellular machinery that reads and interprets the genetic code. Such epigenetic regulation can influence a wide range of cellular processes, including gene expression, DNA repair, and DNA replication. There are several different types of HMTs that can methylate different amino acid residues on histo...

Histone demethylases are enzymes that remove methyl groups from histones. The addition or removal of methyl groups to histones can affect the way that DNA is packaged and, in turn, can regulate gene expression. The discovery of histone demethylases demonstrated that histone methylation is not a permanent modification, but rather a more dynamic process. Role in Biological Processes and Disease Treatment Measuring the activity and inhibition of histone demethylases ...