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Histone Methylation

Histone modifications, such as methylation, acetylation, phosphorylation, citrullination, and sumoylation, are epigenetic marks that regulate chromatin structure and gene expression by influencing DNA accessibility. These modifications are catalyzed by specialized histone-modifying enzymes, including histone acetyltransferases (HATs) and deacetylases (HDACs), histone methyltransferases (HMTs) and demethylases (HDMTs), which dynamically control transcriptional activation or repression.

Conceptual image of a nucleosome with four core histones (H2A, H2B, H3, H4) illustrating acetylation (Ac) and methylation (Me) modifications.

Researchers study histone modifications to understand their roles in development, disease processes like cancer, and to explore potential epigenetic therapies.

Histone Modification Quantification Assays

Standard curve showing colorimetric detection of 5-hmC using the MethylFlash Hydroxymethylated DNA Quantification Kit.

Quantify levels of the most important H3 and H4 marks from histone extracts

Enzymatic Assays

Agarose gel image comparing bisulfite-converted and unconverted DNA samples using the Methylamp DNA Modification Kit

Measure activity and inhibition of HATs, HDACs, HMTs, and HDMTs

Histone Methylation Quantification

Histone methylation is a reversible process by which methyl groups are covalently added to histones. It plays a critical role in regulating gene expression, as it can alter the accessibility of DNA to the cellular machinery that reads and interprets it. Types of Histone Methylation There are several different types of histone methylation, including: Lysine Methylation Lysine methylation can occur at various positions on the hist...

Histone Methyltransferase Assay

Histone methyltransferases (HMTs) are enzymes that catalyze the transfer of methyl groups to histones. Methylation of histones can regulate the accessibility of DNA to the cellular machinery that reads and interprets the genetic code. Such epigenetic regulation can influence a wide range of cellular processes, including gene expression, DNA repair, and DNA replication. There are several different types of HMTs that can methylate different amino acid residues on histo...

Histone Demethylase Assay

Histone demethylases are enzymes that remove methyl groups from histones. The addition or removal of methyl groups to histones can affect the way that DNA is packaged and, in turn, can regulate gene expression. The discovery of histone demethylases demonstrated that histone methylation is not a permanent modification, but rather a more dynamic process. Role in Biological Processes and Disease Treatment Measuring the activity and inhibition of histone demethylases ...

Histone Modification Assays Made Fast & Easy

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