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Signal Transduction Antibodies

Signal Transduction Antibodies

Signal transduction, or cell signaling, is the process by which various signals are transmitted throughout the cell in a cascading series of extracellular and intracellular molecular events involving lipids, proteins, and ions. Often it involves a signal from a secreted growth factor, hormone or other extracellular signaling molecule with binding to receptors at the cell surface, including receptor tyrosine kinases and G-protein coupled receptors, which then transduce the signal intracellularly. A wide range of antibodies are involved in signal transduction, such as cell surface receptor and kinase antibodies, intracellular kinase and adaptor protein antibodies, phosphatase antibodies, and secreted growth factor antibodies. Signaling pathways and their fluid dynamic processes can be studied by researchers aiming to learn more about their far-reaching morphological effects and especially their influence on the regulation of gene expression. Signal transduction antibodies can also offer insight into various pathways and their role in the development of diseases, for example, Alzheimer’s, lupus, cancer and rheumatoid arthritis.
Cell Surface Receptor & Kinase Antibodies
Cell surface receptors transduce signals from the exterior of the cell to the interior by binding to secreted or extracellular factors, including hormones, growth factors, neurotransmitters, or other molecules. Cell surface receptors are generally classified by their tertiary structure or their membrane topology. Cell surface receptors include enzyme-linked receptors, G-protein coupled receptors and ion channel-linked receptors. Transduction of the intracellular signal can be mediated by protein-protein interactions by effector proteins, or by enzymatic activity as in the case of the enzyme-linked receptors. The enzyme-linked receptors usually possess enzymatic activity themselves, or associate with kinases or other enzymatic proteins intracellularly.

Intracellular Kinase & Adaptor Protein Antibodies
After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

Phosphatase Antibodies
Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Secreted Growth Factor Antibodies
Growth factors, peptide hormones, neurotransmitters and other secreted molecules initiate diverse signals involved in controlling cellular growth and proliferation, tissue development and differentiation, cellular metabolism and other biological processes. They initiate signals by binding to a receptor on the cell surface, which then undergoes a conformational change leading to an intracellular signaling cascade.

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Image Description Cat. No. Size Price
14-3-3 (pSer185) Polyclonal Antibody
14-3-3 (pSer185) Polyclonal Antibody

Application: WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Sheep
Purification: Affinity Purified
Reactivity: Cow, Human, Mouse, Rat, Sheep
A-7443-02525 µl $143.00 Discontinued
A-7443-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Beta/Epsilon/Zeta Monoclonal Antibody [3C8]
14-3-3 Beta/Epsilon/Zeta Monoclonal Antibody [3C8]

Application: WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2b
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-0459-100100 µg $431.00 Add to Cart
Antibodies
14-3-3 Beta/Zeta Monoclonal Antibody [2IID8B]
14-3-3 Beta/Zeta Monoclonal Antibody [2IID8B]

Application: ICC, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG
Purification: Affinity Purified
Reactivity: Bovine, Dog, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
A-0458-02525 µg $153.00 Discontinued
A-0458-100100 µg $380.00 Add to Cart
Antibodies
14-3-3 Epsilon (NT) Polyclonal Antibody
14-3-3 Epsilon (NT) Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0653-02525 µl $143.00 Discontinued
A-0653-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Eta Polyclonal Antibody
14-3-3 Eta Polyclonal Antibody

Application: IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0651-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Gamma Polyclonal Antibody
14-3-3 Gamma Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0652-02525 µl $143.00 Discontinued
A-0652-100100 µl $534.00 Add to Cart
Antibodies
14-3-3 Polyclonal Antibody
14-3-3 Polyclonal Antibody

Application: IHC, IP, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken
A-0655-02525 µl $143.00 Discontinued
A-0655-100100 µl $534.00 Add to Cart
Antibodies
14-3-3 Zeta Polyclonal Antibody
14-3-3 Zeta Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0654-02525 µl $143.00 Discontinued
A-0654-100100 µl $499.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody
ABL1 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51765-05050 µg $249.00 Add to Cart
A51765-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, Biotin Conjugated
ABL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51768-05050 µg $249.00 Add to Cart
A51768-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, FITC Conjugated
ABL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51767-05050 µg $249.00 Add to Cart
A51767-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, HRP Conjugated
ABL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51766-05050 µg $249.00 Add to Cart
A51766-100100 µg $349.00 Add to Cart
Antibodies
ACVR1B Polyclonal Antibody
ACVR1B Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58006-05050 µg $249.00 Add to Cart
A58006-100100 µg $349.00 Add to Cart
Antibodies
ACVR1B Polyclonal Antibody, Biotin Conjugated
ACVR1B Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58007-05050 µg $249.00 Add to Cart
A58007-100100 µg $349.00 Add to Cart
Antibodies
ACVR1B Polyclonal Antibody, FITC Conjugated
ACVR1B Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58008-05050 µg $249.00 Add to Cart
A58008-100100 µg $349.00 Add to Cart
Antibodies
ACVR1B Polyclonal Antibody, HRP Conjugated
ACVR1B Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58009-05050 µg $249.00 Add to Cart
A58009-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody
ADAP2 Polyclonal Antibody

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58018-05050 µg $249.00 Add to Cart
A58018-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, Biotin Conjugated
ADAP2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58019-05050 µg $249.00 Add to Cart
A58019-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, FITC Conjugated
ADAP2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58020-05050 µg $249.00 Add to Cart
A58020-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, HRP Conjugated
ADAP2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58021-05050 µg $249.00 Add to Cart
A58021-100100 µg $349.00 Add to Cart
Antibodies
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 2300 products)
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