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Signal Transduction Antibodies

Signal transduction, or cell signaling, is the process by which various signals are transmitted throughout the cell in a cascading series of extracellular and intracellular molecular events involving lipids, proteins, and ions. Often it involves a signal from a secreted growth factor, hormone or other extracellular signaling molecule with binding to receptors at the cell surface, including receptor tyrosine kinases and G-protein coupled receptors, which then transduce the signal intracellularly. A wide range of antibodies are involved in signal transduction, such as cell surface receptor and kinase antibodies, intracellular kinase and adaptor protein antibodies, phosphatase antibodies, and secreted growth factor antibodies. Signaling pathways and their fluid dynamic processes can be studied by researchers aiming to learn more about their far-reaching morphological effects and especially their influence on the regulation of gene expression. Signal transduction antibodies can also offer insight into various pathways and their role in the development of diseases, for example, Alzheimer’s, lupus, cancer and rheumatoid arthritis.

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At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.

Cell Surface Receptor & Kinase Antibodies

Cell surface receptors transduce signals from the exterior of the cell to the interior by binding to secreted or extracellular factors, including hormones, growth factors, neurotransmitters, or other molecules. Cell surface receptors are generally classified by their tertiary structure or their membrane topology. Cell surface receptors include enzyme-linked receptors, G-protein coupled receptors and ion channel-linked receptors. Transduction of the intracellular signal can be mediated by protein-protein interactions by effector proteins, or by enzymatic activity as in the case of the enzyme-linked receptors. The enzyme-linked receptors usually possess enzymatic activity themselves, or associate with kinases or other enzymatic proteins intracellularly.

Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

Phosphatase Antibodies

Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Secreted Growth Factor Antibodies

Growth factors, peptide hormones, neurotransmitters and other secreted molecules initiate diverse signals involved in controlling cellular growth and proliferation, tissue development and differentiation, cellular metabolism and other biological processes. They initiate signals by binding to a receptor on the cell surface, which then undergoes a conformational change leading to an intracellular signaling cascade.

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Displaying 1 to 20 (of 3234 products)

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Description

Cat. No.

Size

Price

ABL1 Polyclonal Antibody

Application:	ELISA, IHC, IP
Areas of Research:	Intracellular Kinase & Adaptor Protein, Signal Transduction
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human
Trial Size Available:	Yes

A51765-020	20 µl	$107.00
A51765-050	50 µl	$275.00
A51765-100	100 µl	$385.00

Antibodies

ABL1 Polyclonal Antibody

Application:	IF, IHC, WB
Areas of Research:	Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse, Rat

A70768-050	50 µl	$275.00
A70768-100	100 µl	$385.00

Antibodies

ABL1 Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Intracellular Kinase & Adaptor Protein, Signal Transduction
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A51768-050	50 µl	$275.00
A51768-100	100 µl	$385.00

Antibodies

ABL1 Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Intracellular Kinase & Adaptor Protein, Signal Transduction
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A51767-050	50 µl	$275.00
A51767-100	100 µl	$385.00

Antibodies

ABL1 Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Intracellular Kinase & Adaptor Protein, Signal Transduction
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A51766-050	50 µl	$275.00
A51766-100	100 µl	$385.00

Antibodies

ABL2 Polyclonal Antibody

Application:	ELISA, WB
Areas of Research:	Cell Structure & Function, Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A69383-020	20 µl	$102.00	Discontinued
A69383-050	50 µl	$256.00	Discontinued
A69383-100	100 µl	$428.00

Antibodies

ABL2 Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Cell Structure & Function, Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A69386-050	50 µl	$267.00
A69386-100	100 µl	$428.00

Antibodies

ABL2 Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Cell Structure & Function, Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A69385-050	50 µl	$267.00
A69385-100	100 µl	$428.00

Antibodies

ABL2 Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Cell Structure & Function, Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A69384-050	50 µl	$267.00
A69384-100	100 µl	$428.00

Antibodies

ACVR1B Polyclonal Antibody

Application:	ELISA, IF
Areas of Research:	Cell Surface Receptor & Kinase, Signal Transduction
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human
Trial Size Available:	Yes

A58006-020	20 µl	$107.00
A58006-050	50 µl	$275.00
A58006-100	100 µl	$385.00

Antibodies

ACVR1B Polyclonal Antibody

Application:	WB
Areas of Research:	Cell Surface Receptor & Kinase
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse

A71893-050	50 µl	$256.00	Discontinued
A71893-100	100 µl	$359.00	Discontinued

Antibodies

ACVR1B Polyclonal Antibody

Application:	WB
Areas of Research:	Cell Surface Receptor & Kinase
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse

A71894-050	50 µl	$275.00
A71894-100	100 µl	$385.00

Antibodies

ACVR1B Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Cell Surface Receptor & Kinase, Signal Transduction
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A58007-050	50 µl	$275.00
A58007-100	100 µl	$385.00

Antibodies

ACVR1B Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Cell Surface Receptor & Kinase, Signal Transduction
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A58008-050	50 µl	$275.00
A58008-100	100 µl	$385.00

Antibodies

ACVR1B Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Cell Surface Receptor & Kinase, Signal Transduction
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A58009-050	50 µl	$275.00
A58009-100	100 µl	$385.00

Antibodies

ACVR2B Recombinant Monoclonal Antibody [7B10] new product

Application:	ELISA, IHC
Areas of Research:	Cell Surface Receptor & Kinase
Clonality:	Monoclonal
Conjugate:	Unconjugated
Host:	HEK293F Cell
Isotype:	Rabbit IgG
Purification:	Affinity Chromatography
Reactivity:	Human
Recombinant:	Yes

A74519-050	50µl	$299.00
A74519-100	100µl	$399.00

Antibodies

ACVRL1 Recombinant Monoclonal Antibody [8B6] new product

Application:	ELISA, IHC, WB
Areas of Research:	Cell Surface Receptor & Kinase
Clonality:	Monoclonal
Conjugate:	Unconjugated
Host:	HEK293F Cell
Isotype:	Rabbit IgG
Purification:	Affinity Chromatography
Reactivity:	Human
Recombinant:	Yes

A74362-050	50µl	$299.00
A74362-100	100µl	$399.00

Antibodies

ADAP2 Polyclonal Antibody

Application:	WB
Areas of Research:	Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Mouse

A71896-050	50 µl	$275.00
A71896-100	100 µl	$385.00

Antibodies

ADAP2 Polyclonal Antibody

Application:	WB
Areas of Research:	Intracellular Kinase & Adaptor Protein
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human

A71897-050	50 µl	$275.00
A71897-100	100 µl	$385.00

Antibodies

ADAP2 Polyclonal Antibody

Application:	ELISA
Areas of Research:	Cellular Structure, Intracellular Kinase & Adaptor Protein, Signal Transduction
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human
Trial Size Available:	Yes

A58018-020	20 µl	$107.00
A58018-050	50 µl	$275.00
A58018-100	100 µl	$385.00

Antibodies

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Displaying 1 to 20 (of 3234 products)

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