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   Home  »  Research Kits  »  Other Histone Modifications  »  Sumoylation 
  Quote Lookup

Sumoylation

Introduction

SUMOylation is a post-translational modification process that involves the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to lysine residues on target proteins. This process is reversible and can be regulated by enzymes called SUMO proteases.

Regulation of Cellular Processes

SUMOylation plays a role in the regulation of various cellular processes, including transcription, protein stability, nuclear-cytosolic transport, protein-protein interactions, cellular localization, apoptosis, DNA repair, stress response, and cell cycle progression. Dysregulation of SUMOylation has been linked to the development of various diseases. For example, SUMOylation of certain transcription factors is essential for proper gene regulation in cancer cells, and abnormal SUMOylation of proteins has been observed in the brains of individuals with neurodegenerative diseases such as Alzheimer's and Parkinson's.

Detection and Implications

The detection of in vivo protein SUMOylation can provide insight into the function of proteins and their role in various cellular processes. This can be useful for understanding the underlying mechanisms of diseases in which SUMOylation is disrupted and for identifying potential therapeutic targets for these diseases. Additionally, studying SUMOylation may provide insight into how to target and modulate specific proteins in order to manipulate their function.

Summary

  • SUMOylation is a post-translational modification process involving the attachment of SUMO proteins to target proteins.
  • It is involved in the regulation of various cellular processes and its dysregulation has been linked to the development of various diseases.
  • Detection of in vivo protein SUMOylation can provide insight into protein function and the underlying mechanisms of diseases.
  • Understanding SUMOylation may provide insight into targeting and modulating specific proteins for therapeutic purposes.
Result Pages:  1  Displaying 1 to 3 (of 3 products)
Image Description Cat. No. Size Price
EpiQuik In Vivo Universal Protein Sumoylation Assay Kit
EpiQuik In Vivo Universal Protein Sumoylation Assay Kit

Citations (5) | (1)
Input Type: Nuclear Extracts
Research Area: Sumoylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-8001-4848 assays $402.00 Add to Cart
P-8001-9696 assays $646.00 Add to Cart
Research Kits
EpiQuik In Vivo HDAC1 Sumoylation Assay Kit
EpiQuik In Vivo HDAC1 Sumoylation Assay Kit

Input Type: Nuclear Extracts
Research Area: Sumoylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-8002-4848 assays $458.00 Add to Cart
P-8002-9696 assays $758.00 Add to Cart
Research Kits
EpiQuik In Vivo Protein Sumoylation Assay Ultra Kit (Colorimetric)
EpiQuik In Vivo Protein Sumoylation Assay Ultra Kit (Colorimetric)

Citations (1)
Input Type: Nuclear Extracts
Research Area: Sumoylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-8003-4848 assays $379.00 Add to Cart
P-8003-9696 assays $646.00 Add to Cart
Research Kits
Result Pages:  1  Displaying 1 to 3 (of 3 products)
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