Browse practical epigenetics articles, application notes, and research resources organized by topic. Use search to quickly locate guidance relevant to your workflow.
Learn how H3K27ac marks active enhancers, why enhancer activation matters in cell-state plasticity, and how to choose assays for global H3K27ac, histone modification profiling, and locus-specific chromatin...
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It would be a near impossible feat for the human genome, consisting of some 3 billion bases, to fit within its relatively miniscule cellular accommodations if not for the help of a family of very critical...
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In the early 1960s, Vincent G. Allfrey and his colleagues at the Rockefeller Institute (today’s Rockefeller University) demonstrated by way of C14 labeling the incorporation of methyl and acetyl groups into...
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Post-translational modifications (PTMs) of histones, including methylation, acetylation, and phosphorylation, have been defined as epigenetic modifiers that can regulate chromatin structure and transcription....
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Histones are the main protein constituent of chromatin, acting as spools around which DNA winds and compacts. They can undergo various posttranslational modifications (e.g., methylation, acetylation,...
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An overview of the major histone modification enzymes including HMTs, HATs, HDMTs, and HDACs
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A detailed guide to histone modifications investigated in epigenetic research
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