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   Home  »  Research Kits  »  RNA Methylation 
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RNA Methylation

RNA methylation, such as N6-methyladenosine (m6A), is a key epigenetic modification where methyl groups are added to RNA nucleotides by RNA methyltransferases, like METTL3/14, influencing RNA stability, splicing, translation, and cellular function. This modification is reversible, as RNA demethylases, including FTO and ALKBH5, can remove methyl groups, allowing for dynamic regulation of gene expression.

Chemical diagram illustrating N6-methylation of adenosine in RNA by METTL3 (using SAM as a methyl donor) and demethylation by FTO or ALKBH5 (requiring Fe(II) and 2OG).

Researchers study RNA methylation to understand its roles in development and diseases, as well as to explore its potential for novel therapeutic and diagnostic applications.

Global RNA Modification Quantification Assays

Bar graph showing percentage of 5-methylcytosine (%5-mC) in various DNA sample inputs using the MethylFlash Global DNA Methylation ELISA Kit.

Quantify levels of m6A, 5-mC, or 8-OhG in total RNA

Enzymatic Assays

Agarose gel image comparing bisulfite-converted and unconverted DNA samples using the Methylamp DNA Modification Kit

Measure activity and inhibition of RNA methylases and demethylases

Transcriptome-Specific RNA Methylation

Sanger sequencing chromatograms

Bisulfite and CUT&RUN-based MeRIP assays for methylated RNA analysis

Featured RNA Methylation Kits

  m6A RNA Methylation Quantification Kit CUT&RUN m6A RNA Enrichment (MeRIP) Kit 5-mC RNA Methylation ELISA Easy Kit
 

m6A RNA Methylation Quantification Kit Cat #P-9005

CUT&RUN m6A RNA Enrichment (MeRIP) Kit Cat #P-9018

5-mC RNA Methylation ELISA Easy Kit Cat #P-9009

Purpose An ELISA-like format for absorbance-based quantitation of N6-methyladenosine in RNA RNA immunoprecipitation (MeRIP) based on CUT&RUN for increased specificity and signals An ELISA-like format for fluorescence-based quantitation of 5-mC RNA methylation
Key Points
  • Detect m6A RNA methylation in any species
  • Colorimetric ELISA-like assay using an m6A antibody
  • Detection limit as low as 10 pg of m6A
  • High Enrichment of m6A
  • Low Sample Requirement
  • Minimal MeRIP/sequencing background
  • Large signal window, low background noise
  • Detect 5-mC RNA methylation in any species
  • High specificity to 5-mC, with no cross-reactivity
Starting Material Total RNA Total RNA Nuclear Extracts, Purified Enzymes
Lowest Input Amount 100 ng 1 µg - 20 µg 50 ng to 300 ng
Total Protocol Time < 4 hours < 3 hours < 3 hours
Reactions 48,96 24 8,96
Vessel Format 96-Well Plate Columns/Tubes 96-Well Plate
Global RNA Methylation
Our ELISA-based assays are a simple and convenient way to rapidly screen global RNA modifications, prior to more in-depth and costly approaches like qPCR and NGS. Choose y...

Transcriptome-Specific RNA Methylation
Established methods used for epitranscriptome-wide m6A mapping like MeRIP-seq, PA-m6A-seq, and miCLIP have either been widely used but are unable to achieve high resolution in m6A profiling, or improve the profiling resolution but suffer from poor reproducibility and a complicated process. In parti...

RNA Methylation Activity/Inhibition
The formation of m6A RNA appears to be a co-transcriptional event taking place early on in the RNA lifecycle and is mediated by a multi-protein methyltransferase complex composed, in part, of METTL enzymes. Chemical addition of a methyl group at the nitrogen-6 position of adenosine (A) residues to form m6A occurs via the MET...

Result Pages:  1  Displaying 1 to 10 (of 10 products)
Image Description Cat. No. Size Price
Methylamp RNA Bisulfite Conversion Kit
Methylamp RNA Bisulfite Conversion Kit

Citations (7)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Sample Modification
Vessel Format: Columns/Tubes
P-9003-05050 reactions $199.00 Add to Cart
Research Kits
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Citations (741) | (12)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9005-4848 reactions $352.00 Add to Cart
P-9005-9696 reactions $581.00 Add to Cart
Research Kits
EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina)
EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina)

Citations (2)
Input Type: RNA
Research Area: Next Gen Sequencing, RNA Methylation
Target Application: Library Construction, Sample Modification
Vessel Format: 96-Well Plate
P-9007-1212 reactions $599.00 Add to Cart
P-9007-2424 reactions $1,173.00 Add to Cart
Research Kits
EpiQuik m6A RNA Methylation Quantification Kit (Fluorometric)
EpiQuik m6A RNA Methylation Quantification Kit (Fluorometric)

Citations (15) | (1)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9008-4848 assays $352.00 Add to Cart
P-9008-9696 assays $581.00 Add to Cart
Research Kits
MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric)
MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric)

Citations (16)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9009-4848 reactions $359.00 Add to Cart
P-9009-9696 reactions $593.00 Add to Cart
Research Kits
Epigenase m6A Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase m6A Demethylase Activity/Inhibition Assay Kit (Colorimetric)

Citations (8)
Input Type: Nuclear Extracts, Purified Enzymes
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9013-4848 assays $399.00 Add to Cart
P-9013-9696 assays $646.00 Add to Cart
Research Kits
MethylFlash Urine N6-methyladenosine (m6A) Quantification Kit (Colorimetric)
MethylFlash Urine N6-methyladenosine (m6A) Quantification Kit (Colorimetric)

Input Type: Urine
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9015-4848 assays $364.00 Add to Cart
P-9015-9696 assays $599.00 Add to Cart
Research Kits
EpiNext CUT&RUN RNA m6A-Seq Kit
EpiNext CUT&RUN RNA m6A-Seq Kit

Citations (4) | (1)
Input Type: RNA
Research Area: Next Gen Sequencing, RNA Methylation
Target Application: Library Construction, Sample Modification
Vessel Format: Columns/Tubes
P-9016-1212 reactions $660.00 Add to Cart
P-9016-2424 reactions $1,158.00 Add to Cart
Research Kits
EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit

Citations (106)
Input Type: RNA
Research Area: Next Gen Sequencing, RNA Methylation
Target Application: Library Construction, Sample Modification
Vessel Format: Columns/Tubes
P-9018-2424 reactions $453.00 Add to Cart
Research Kits
Epigenase m6A Methylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase m6A Methylase Activity/Inhibition Assay Kit (Colorimetric)

Citations (7)
Input Type: Nuclear Extracts, Purified Enzymes
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9019-4848 assays $398.00 Add to Cart
P-9019-9696 assays $633.00 Add to Cart
Research Kits
Result Pages:  1  Displaying 1 to 10 (of 10 products)
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