Histone Methylation (Lysine) Antibodies

Histone lysine methylation is a well-established transcriptional mechanism for regulating gene expression in eukaryotic cells. Histone N-terminal tails are susceptible to post-translational modifications (PTMs) and can influence many biological processes, such as transcription, replication, and chromosome maintenance.

Methylation Patterns

Methylation of lysine residues can occur at different positions on the histone, and this can have different effects on gene expression. For example, methylation of lysine 4 on histone H3 (H3K4me) is typically associated with active gene expression, while methylation of lysine 27 on histone H3 (H3K27me) is linked to repressed gene expression.

The methylation patterns on histones are tightly controlled by lysine methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability. KMTs are enzymes that transfer a methyl group to a specific lysine residue on a histone, whereas KDMs facilitate methyl group removal. The balance between the activity of these enzymes ensures that the proper patterns are maintained. Dysregulation of this process can lead to a variety of diseases, including cancer.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

• No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
• 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
• Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
• Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.