Whole Genome Bisulfite Sequencing (WGBS) Service

Whole Genome Bisulfite Sequencing (WGBS) is a bisulfite sequencing method to detect in-depth DNA methylation across the entire genome, including methylation at CpG sites and less common non-CpG site such as CNG.

WGBS is the gold standard for bisulfite based DNA methylation studies as the entire genome is sequenced with base-level detail into where every methylated cytosine is located.

Why WGBS With Us?
Service #S-1CMS
Complete genome coverage of methylation at
every CpG site and less common non-CpG
sites such as CNG
End-to-End Package:
Includes everything from bisulfite treatment to data analysis
FASTQ raw data, FASTQC quality control insights, read mapping, methylation calling and differential methylation analysis.
Rapid Turnaround Time:
4 – 8 weeks from sample submission*
Sequencing & Library Preparation Guarantee:
Library QC by Bioanalyzer, KAPA quantification
and Q30 sequencing score > 75%
High Sequencing Depth:
Starting at 20X sequencing depth on PE150 lanes**
Post-Completion Technical Support:
Complimentary high-quality support to assist with data analysis at no additional charge

*Time measured when pre-payment for service is received

**Assuming 1 human library per lane

Assuming 8 isolated human DNA samples submitted
and placed across 8 PE150 lanes (enough to fill a flow cell)

What EpiGentek Provides

Example Data

Whole Genome Bisulfite Sequencing Data & Figures
*These are examples of data that may be provided. Please consult your service representative regarding the exact data you will receive.

Sample Requirements

Epigenetic Services Sample Requirements

We currently accept DNA, cell, and tissue samples for our Whole Genome Bisulfite Sequencing Methyl-Seq service. Proper sample preparation along with the appropriate quality control methods on your end will allow the greatest chance for assay success. Please follow all guidelines for sample requirements, packaging and labeling, and shipping which are outlined on the Submission Instructions page.

Talk to a Scientist


Want more information on our Whole Genome Bisulfite Sequencing Methyl-Seq service or interested in customizing your research project? We’re here to help! Get in touch with one of our highly knowledgeable epigenetic services experts by calling toll-free at 1-877-374-4368 or emailing services @ epigentek.com.