During specific pathological, environmental, or developmental states, global DNA methylation levels can be altered in the genome. DNA hypomethylation or hypermethylation has been used as a molecular marker in numerous biological processes, including cancer. Therefore, the accurate measurement of total 5-mC levels can help epigenetic researchers to better understand the role DNA methylation plays in biological processes and the disruption of such processes.
Using an ELISA-based assay, EpiGentek’s proprietary global 5-mC quantification service quantifies global DNA methylation by specifically measuring 5-methylcytosine (5-mC) levels with highly accurate, reliable results. Measuring global DNA methylation status is useful for identifying the distribution of this base (5-mC) in different cell types and various areas of the genome.
Quantitate total methylated cytosine levels in DNA on a global scale.
We currently accept DNA, cell, and tissue samples for our Global 5-mC Quantification service. Proper sample preparation along with the appropriate quality control methods on your end will allow the greatest chance for assay success. Please follow all guidelines for sample requirements, packaging and labeling, and shipping which are outlined on the Submission Instructions page.
Talk to a Scientist
Want more information on our Global 5-mC Quantification service or interested in customizing your research project? We’re here to help! Get in touch with one of our highly knowledgeable epigenetic services experts by calling toll-free at 1-877-374-4368 or emailing services @ epigentek.com.