DNA methylation is an important epigenetic modification that plays a key role in the regulation of gene expression. It involves the addition of a methyl group to cytosine bases in the DNA molecule and can occur at specific sites in the genome known as CpG islands. Methylation can affect the way that genes are expressed by either activating or silencing them, depending on the specific context and location in the genome.
Importance of Global DNA Methylation Quantification
Global quantification of DNA methylation is important because it allows researchers to assess the overall level of methylation in a genome or specific region of interest. This can provide important insights into the biological processes that are regulated by methylation, as well as the potential roles of methylation in various diseases and conditions.
- Abnormal DNA methylation patterns have been linked to cancer, neurological diseases, and cardiovascular diseases.
- Quantifying DNA methylation at the global level can help identify changes in methylation patterns associated with these diseases.
- This information may be used to develop new therapies or diagnostic approaches.
Overall, global quantification of DNA methylation is a crucial tool in the study of gene expression and the regulation of biological processes, and has the potential to improve our understanding of a wide range of diseases and conditions.