ISAC-Seq (In Situ Accessible Chromatin Sequencing) is the latest innovation in in situ chromatin accessibility sequencing, delivering rapid, low-bias, genome-wide maps of open/closed chromatin and nucleosome and transcription factor positioning.
The ISAC-Seq assay offers a fast, streamlined workflow that generates sequencing-ready libraries in under two hours. Its sequence-independent cleavage technology minimizes bias and provides broader, more accurate coverage of accessible chromatin sites compared to traditional ATAC-seq methods.
EpigenTek delivers all-in-one ISAC-Seq and other resources to support and streamline your chromatin accessibility studies:
- Explore the Basics: Learn the fundamentals of ISAC-Seq
- Additional Resources: Explore our detailed overview and supporting materials
- Technical Hub: Find FAQs, troubleshooting solutions, and optimization guides in our centralized support center.



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