Target site-specific histone modifications directly and indirectly impact transcriptional regulation and the direction of various cellular processes. The biological influences achieved by various histone modifying enzymes eventually require that histone be modified. Epigenetic modifications can be modulated by directly inhibiting modifying enzymes or blocking co-factor recruiting pathways. Development of these modulators would lead to the development of new therapeutic agents and improvement in disease treatment, especially cancer therapy.
Quantification With Us?
Includes everything from sample preparation to data analysis
Accurate readout of H3 or H4 modification target
3 - 5 weeks from sample submission*
Target any H3 or H4 histone modification antibody in our catalog
Each sample tested in duplicate for no additional fee
All kits used in service are commercially available in our catalog
Complimentary high-quality support to assist with data analysis included
*Time measured when pre-payment for service is received
**Assuming 96 isolated histone samples submitted, 1 histone modification antibody target
We currently accept histone extracts, cells, and tissue for our Histone Modification Quantification service. Proper sample preparation along with the appropriate quality control methods on your end will allow the greatest chance for assay success. Please follow all guidelines for sample requirements, packaging and labeling, and shipping which are outlined on the Submission Instructions page.
Talk to a Scientist
Want more information on our Histone Modification Profiling and Drug Discovery services or interested in customizing your research project? We’re here to help! Get in touch with one of our highly knowledgeable epigenetic services experts by calling toll-free at 1-877-374-4368 or emailing services @ epigentek.com.