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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.
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Image Description Cat. No. Size Price
14-3-3 (pSer185) Polyclonal Antibody
14-3-3 (pSer185) Polyclonal Antibody

Application: WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Sheep
Purification: Affinity Purified
Reactivity: Cow, Human, Mouse, Rat, Sheep
A-7443-02525 µl $143.00 Discontinued
A-7443-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Beta/Epsilon/Zeta Monoclonal Antibody [3C8]
14-3-3 Beta/Epsilon/Zeta Monoclonal Antibody [3C8]

Application: WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2b
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-0459-100100 µg $431.00 Add to Cart
Antibodies
14-3-3 Beta/Zeta Monoclonal Antibody [2IID8B]
14-3-3 Beta/Zeta Monoclonal Antibody [2IID8B]

Application: ICC, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG
Purification: Affinity Purified
Reactivity: Bovine, Dog, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
A-0458-02525 µg $153.00 Discontinued
A-0458-100100 µg $380.00 Add to Cart
Antibodies
14-3-3 Epsilon (NT) Polyclonal Antibody
14-3-3 Epsilon (NT) Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0653-02525 µl $143.00 Discontinued
A-0653-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Eta Polyclonal Antibody
14-3-3 Eta Polyclonal Antibody

Application: IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0651-100100 µl $499.00 Add to Cart
Antibodies
14-3-3 Gamma Polyclonal Antibody
14-3-3 Gamma Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0652-02525 µl $143.00 Discontinued
A-0652-100100 µl $534.00 Add to Cart
Antibodies
14-3-3 Polyclonal Antibody
14-3-3 Polyclonal Antibody

Application: IHC, IP, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken
A-0655-02525 µl $143.00 Discontinued
A-0655-100100 µl $534.00 Add to Cart
Antibodies
14-3-3 Zeta Polyclonal Antibody
14-3-3 Zeta Polyclonal Antibody

Application: AFC, ELISA, IHC, WB
Areas of Research: Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Serum
Reactivity: Chicken, Cow, Human, Mouse, Rat, Sheep
A-0654-02525 µl $143.00 Discontinued
A-0654-100100 µl $499.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody
ABL1 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51765-05050 µg $249.00 Add to Cart
A51765-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, Biotin Conjugated
ABL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51768-05050 µg $249.00 Add to Cart
A51768-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, FITC Conjugated
ABL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51767-05050 µg $249.00 Add to Cart
A51767-100100 µg $349.00 Add to Cart
Antibodies
ABL1 Polyclonal Antibody, HRP Conjugated
ABL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51766-05050 µg $249.00 Add to Cart
A51766-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody
ADAP2 Polyclonal Antibody

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58018-05050 µg $249.00 Add to Cart
A58018-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, Biotin Conjugated
ADAP2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58019-05050 µg $249.00 Add to Cart
A58019-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, FITC Conjugated
ADAP2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58020-05050 µg $249.00 Add to Cart
A58020-100100 µg $349.00 Add to Cart
Antibodies
ADAP2 Polyclonal Antibody, HRP Conjugated
ADAP2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58021-05050 µg $249.00 Add to Cart
A58021-100100 µg $349.00 Add to Cart
Antibodies
ADRBK1 Polyclonal Antibody
ADRBK1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53488-05050 µg $249.00 Add to Cart
A53488-100100 µg $349.00 Add to Cart
Antibodies
ADRBK1 Polyclonal Antibody, Biotin Conjugated
ADRBK1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53485-05050 µg $249.00 Add to Cart
A53485-100100 µg $349.00 Add to Cart
Antibodies
ADRBK1 Polyclonal Antibody, FITC Conjugated
ADRBK1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53486-05050 µg $249.00 Add to Cart
A53486-100100 µg $349.00 Add to Cart
Antibodies
ADRBK1 Polyclonal Antibody, HRP Conjugated
ADRBK1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53487-05050 µg $249.00 Add to Cart
A53487-100100 µg $349.00 Add to Cart
Antibodies
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