Histone Deacetylation Antibodies

Histone deacetylation is the process by which acetyl groups are removed from the lysine residues of histone proteins, and can be investigated using HDAC antibodies. Acetylation of histones can alter the structure of chromatin and affect the accessibility of the genetic material to DNA polymerases and transcription factors. Histone deacetylation is typically associated with the repression of gene expression, as the condensed chromatin structure, also known as heterochromatin, makes it more difficult for the transcription machinery to access the DNA.

Histone deacetylation plays a crucial role in regulating gene expression, cell growth, and differentiation, and is catalyzed by a family of enzymes called histone deacetylases (HDACs). Deviations from normal HDAC activity can promote aberrant transcription of genes regulating cell proliferation and apoptosis, promoting tumor growth and metastasis. Some cancer drugs, such as HDAC inhibitors, target the HDAC enzymes and prevent histone deacetylation in order to induce cancer cell death or differentiation.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

• No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
• 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
• Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
• Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.