BackgroundHistone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
DescriptionHDAC1 Recombinant Monoclonal Antibody [10A1]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ13547
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human HDAC1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesHistone deacetylase 1 (HD1) (EC 3.5.1.98), HDAC1, RPD3L1
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000