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EpiQuik Nuclear Extraction Kit


For the isolation and extraction of nuclear proteins from cells or tissues while keeping enzymatic activity intact

Citations (282) | Write a Review
To demonstrate the quality of the materials and protocol of the EpiQuik Nuclear Extraction Kit, nuclear extracts were prepared from MCF-7 cells and the activity of HDACs were measured using different amounts of the extract. The result shown in the figure demonstrates the kit's high specificity.
Input Type: Unisolated Samples
Research Area: DNA Methylation, Histone Acetylation, Histone Methylation, Sumoylation
Target Application: Sample Isolation
Vessel Format: Columns/Tubes
100% Guarantee: 6 months
Catalog No.SizePriceQty
OP-0002-1100 assays $167.00 
Order within 8 hr 8 min & get it by tomorrow 
Product Overview

The EpiQuik™ Nuclear Extraction Kit is a complete set of optimized reagents to provide a simple and selective method for isolating nuclear proteins used for a variety of applications in just 60 minutes. These applications may include Western blot, protein-DNA binding assays, nuclear enzyme assays, and any other procedures requiring optimized nuclear proteins. The protocol is fast and easy-to-use, and also isolates very abundant yields of nuclear extract from mammalian cells or tissue samples. The kit is also specifically designed to meet the requirements of nuclear extracts used in various other epigenetic products from Epigentek, including DNMTHDAC, and HAT assays. Some of the kit's highlighted features include the following:

The EpiQuik™ Nuclear Extraction Kit has the following highlighted advantages and features: 

  • Fast - Pre-optimized and simple step-wise 1-hour protocol.
  • Convenient – The kit includes all essential reagents to carry out a nuclear extraction.
  • High Yield – Total yield can be up to 100 µg per optimal extraction (results may vary depending on cell or tissue type).
  • Consistent - Standardized procedure for reproducible results.
  • Quality Controlled – EpiGentek guarantees the performance of the EpiQuik™ Nuclear Extraction kit in the manner described in the provided product instructions

Nuclear extraction is the procedure of parting the nuclear and cytoplasmic portions of the cell. The process can be beneficial in examining the molecules that specifically interact with the nucleus, such as transcription factors which bind DNA.

Effective nuclear protein extraction is a vital step in applications revolving around nuclear, epigenetic, or genetic processes. This step helps provide high-quality starting materials for the characterization of the function, structure, and interactions of the nuclear proteins as well as allowing for various downstream analyses.  

What used to be done by following a non-standardized protocol of combining various standard lab ingredients has been made quick and easy with the introduction of kits like the EpiQuik™ Nuclear Extraction kit, which provides all materials necessary for the procedure and takes as little as an hour for the entire process to complete.

Principle & Procedure
The EpiQuik™ Nuclear Extraction Kit simply applies our proprietary nuclear protein isolation buffers to cell/tissues. After treatment with pre-lysis and lysis buffers, the nuclear proteins are easily extracted for immediate use or storage at proper conditions.

Starting Materials & Yield
A total of 100 standard extractions (using 10^7 cells or 20 mg tissues) can be isolated from mammalian cells or tissue samples with this kit. 

Frequently Asked Q's

1. Should DTT be added into NE1 for tissue extraction?
It is not necessary.

2. How many rpm should be used for centrifuging the cell extract if using a desktop centrifuge?
12,000-14,000 rpm.

3. What should I do if the addition of 5 µl NE2 into 1 M of cells cannot suspend the nuclei?
Add more NE2. For example, add 10 µl to 1 M nuclei.

User Guide & MSDS

[User Guide]*
*Always use the actual User Guide that shipped with your product. Is the above file locked? You can also request user guides by emailing info@epigentek.com along with your contact information and institution name.

[Safety Data Sheet]
Product Citations

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Meng M et. al. (August 2016). Novel immunostimulators with a thiazolidin-4-one ring promote the immunostimulatory effect of human iNKT cells on the stimulation of Th2-like immune responsiveness via GATA3 activation in vitro. Int Immunopharmacol. 39:353-358.

Xiaomei Wang et. al. (June 2016). Lipid reduces GLP-1 production via inhibiting NF-κB p65 and IL-6 in intestinal L cells and pancreatic alpha cells IJCEP. 9(6)

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Herencia C et. al. (June 2016). Procaine Inhibits Osteo/Odontogenesis through Wnt/β-Catenin Inactivation. PLoS One. 11(6):e0156788.

Hu C et. al. (June 2016). Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages. J Leukoc Biol.

Yang T et. al. (June 2016). Hepatocyte growth factor induced differentiation of bone mesenchymal stem cells towards hepatocyte-like cells occurs through nuclear factor-kappa B signaling in vitro. Cell Biol Int.

Nozik-Grayck E et. al. (May 2016). Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. :ajplung.00263.2015.

Iglesias González T et. al. (May 2016). New strategy to address DNA-methyl transferase activity in ovarian cancer cell cultures by monitoring the formation of 5-methylcytosine using HPLC-UV. J Chromatogr B Analyt Technol Biomed Life Sci. 1028:16-24.

Navakauskienė et. al. (May 2016). Histone demethylating agents as potential S-adenosyl-L-methionine-competitors Med Chem Comm.

Gang Yu et. al. (April 2016). Ozone therapy could attenuate tubulointerstitial injury in adenine-induced CKD rats by mediating Nrf2 and NF-κB IJBMS. 19(10)

Muta K et. al. (March 2016). Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension Nephrol Dial Transplant.

Iwanowycz S et. al. (March 2016). Emodin bi-directionally modulates macrophage polarization and epigenetically regulates macrophage memory. J Biol Chem.

Moriyama T et. al. (March 2016). Atrial natriuretic peptide attenuation of renal ischemia–reperfusion injury after major surgery J Surg Res. 201(1):213-218.

Huang F et. al. (March 2016). Interleukin‑1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model Oncol Lett.

Zhang Y et. al. (February 2016). 2-Methoxyestradiol prevents monocyte adhesion to vascular endothelial cells via downregulation of VCAM-1 expression. Gynecol Endocrinol. :1-6.

Tang SC et. al. (January 2016). Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells. DNA Cell Biol.

Li Y et. al. (January 2016). HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc. Cancer Res. 76(2):293-304.

Zhang X et. al. (January 2016). Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 7:10376.

Sakamoto T et. al. (January 2016). A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer. PLoS One. 11(1):e0145985.

Bott AJ et. al. (December 2015). Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab. 22(6):1068-77.

Yasuda H et. al. (November 2015). Exendin-4 promotes extracellular-superoxide dismutase expression in A549 cells through DNA demethylation J Clin Biochem Nutr.

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