Sitewide 2017 Summer Sale Site-wide summer sale! Take 10% off your entire order when using code E1707SUN. » Learn More
Epigentek Home
Epigentek Free Shipping

EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit


Citations (125) | Write a Review
Schematic procedure for using the EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit.
Histone extracts were prepared from MDA-231 cells using the EpiQuik Total Histone Extraction Kit (Cat. No. OP-0006) and the amount of dimethyl-H3-K4 was measured using the EpiQuik Dimethyl Histone H3-K4 Quantification kit (Colorimetric).
HSC-3 cells were incubated with/without zebularine (220 mM) for 48 hours. Nuclear proteins were extracted and total DNMT activity was measured.
Input Type: DNA
Research Area: DNA Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
100% Guarantee: 6 months
Catalog No.SizePriceQty
P-3001-148 assays $317.00 
P-3001-296 assays $534.00 
Availability: Usually Ships In 1-2 Days 
Product Overview

We recommend using a newer version of this product: EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric)

The EpiQuik™ DNA Methyltransferase Activity/Inhibition Assay Kit is a complete set of optimized buffers and reagents that allows the experimenter to measure DNA methyltransferase activity or inhibition at extremely fast speeds. The kit is ready-to-use and provides all the essential components needed to carry out a successful DNMT activity/inhibition experiment without the need for radioactivity or any special equipment. The EpiQuik™ DNA Methyltransferase Activity/Inhibition Assay Kit is suitable for measuring DNMT activity/inhibition from a broad range of species including mammalian cells/tissues, plants, and bacteria. The kit has the following advantages:

  • Very rapid procedure, which can be completed within 3 hours.
  • Safe and innovative colorimetric assay without radioactivity, extraction, and chromatography.
  • Strip microplate format makes the assay flexible: manual or high throughput analysis.
  • Extremely simple, reliable, and consistent assay conditions.

Principle & Procedure
The EpiQuik™ DNA Methyltransferase Activity/Inhibition Assay Kit is designed for measuring total DNMT activity (de novo, maintenance). In an assay with this kit, the unique cytosine-rich DNA substrate is stably coated on the strip wells. These wells are specifically treated to have a high DNA absorption ability. DNMT enzymes transfer a methyl group to cytosine from Adomet to methylate DNA substrate. The methylated DNA can be recognized with an anti-5-methylcytosine antibody. The ratio or amount of methylated DNA, which is proportional to enzyme activity, can then be colorimetrically quantified through an ELISA-like reaction.

Product Components

M1 (10X Wash Buffer)
M2 (DNMT Assay Buffer)
M3 (Adomet, 8 mM)*
M4 (DNMT Positive Control)*
M5 (Capture Antibody)*
M6 (Detection Antibody, 200 µg/ml)*
M7 (Developing Solution)
M8 (Stop Solution)
8-Well Substrate-Coated Strip (with Frame)
User Guide

*For maximum recovery of the products, centrifuge the original vial after thawing prior to opening the cap.

Frequently Asked Q's

1. Can protein extracts from frozen tissue stored at -80°C be used with this kit?
No, protein extracts should be used from fresh tissue.

2. What is the minimum amount of Dnmt protein required for a successful assay?
The minimum amount of DNMT protein is about 0.2 µg for a successful assay.

3. Do I have to do all the assays at once with the kit or can I do them in portions?
Yes, you can do them in portions by using only the reagent amounts you need, including diluting M5 and M6 as needed.

4. How do you aspirate the washing solution from the wells?
By using pipette tips.

5. How long can M5 and M6 be stored for after dilution?
1 or 2 days.

6. Can this kit distinguish Dnmt1 and Dnmt3a/3b?
The P-3001 kit cannot distinguish between Dnmt1 and Dnmt3a/3b. It will work well with both enzymes.

7. How are the wells coated?
The wells are coated with a proprietary Dnmt binding substance (high affinity).

8. Is there any reason why I cannot start with recombinant DNMT1, incubate with my inhibitors, and then use this to proceed with the assay?
This kit is suitable for measuring Dnmt activity of both cell extract and recombinant Dnmts (including Dnmt1) in the absence or presence of inhibitors. The capture mAb included in this kit is against converted (methylated) substrate.

User Guide & MSDS

[User Guide]*
*Always use the actual User Guide that shipped with your product. Is the above file locked? You can also request user guides by emailing along with your contact information and institution name.

[Material Safety Data Sheet]
Product Citations

Daifuku R et. al. (July 2017). 5-aza-2',2'-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer. Pharmaceuticals (Basel). 10(3)

Sagarkar S et. al. (June 2017). Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in rat amygdala: A possible role in anxiety-like behaviors. Neurobiol Dis. 106:101-109.

Kozuka C et. al. (May 2017). Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia.

Prasad R et. al. (May 2017). Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin. Sci Rep. 7(1):1657.

Geyer KK et. al. (May 2017). The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Negl Trop Dis. 11(5):e0005246.

Sagarkar S et. al. (April 2017). Traumatic stress-induced persistent changes in DNA methylation regulate neuropeptide Y expression in rat jejunum. Neurogastroenterol Motil.

Wang Z et. al. (April 2017). Artesunate Suppresses the Growth of Prostatic Cancer Cells through Inhibiting Androgen Receptor. Biol Pharm Bull. 40(4):479-485.

Gong Z et. al. (March 2017). Widespread 5-methylcytosine in the genomes of avian Coccidia and other apicomplexan parasites detected by an ELISA-based method. Parasitol Res.

Haixia Wei et. al. (March 2017). Characterization of Cytosine Methylation and the DNA Methyltransferases of Toxoplasma gondii IJBS. 13(4):458-470.

Zhouwei Wu et. al. (March 2017). Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients Journal of Dermatological Science.

Yang Y et. al. (March 2017). Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells. AAPS J. 19(2):421-430.

Kanwal R et. al. (September 2016). Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. PLoS One. 11(9):e0162956.

Liu H et. al. (August 2016). Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med. 8(353):353ra113.

Li Y et. al. (August 2016). Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals. Epigenomics. 8(8):1019-37.

Herencia C et. al. (June 2016). Procaine Inhibits Osteo/Odontogenesis through Wnt/β-Catenin Inactivation. PLoS One. 11(6):e0156788.

Garella D et. al. (May 2016). Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors. Chem Biol Drug Des.

Zhong J et. al. (March 2016). The green tea polyphenol EGCG alleviates maternal diabetes-induced neural tube defects by inhibiting DNA hypermethylation. Am J Obstet Gynecol.

Joshi M et. al. (February 2016). Ensemble based virtual screening and experimental validation of inhibitors targeting a novel site of human DNMT1. Chem Biol Drug Des.

Sun R et. al. (September 2015). Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking. Int J Clin Exp Med. 8(9):15773-9.

Granados ML et. al. (September 2015). Contributions of the Epidermal Growth Factor Receptor to Acquisition of Platinum Resistance in Ovarian Cancer Cells. PLoS One. 10(9):e0136893.

Neveu WA et. al. (September 2015). TGFβ1 epigenetically modifies Thy-1 expression in primary lung fibroblasts. Am J Physiol Cell Physiol. :ajpcell.00086.2015.

Chen Y et. al. (August 2015). Prenatal glucocorticoid contributed to rat lung dysplasia is related to asymmetric dimethylarginine/nitric oxide pathway Science Bulletin. 60(16):1416-1425.

Kim AY et. al. (July 2015). Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun. 6:7585.

Peng X et. al. (June 2015). 3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21. Cancer Prev Res (Phila). 8(6):509-17.

Liu CM et. al. (May 2015). Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-κB pathway. Food Chem Toxicol.

Bian Y et. al. (February 2015). Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. J Cell Physiol.

Chen S et. al. (November 2014). Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening. J Med Chem. 57(21):9028-41.

Lai J et. al. (August 2014). TAp73 and ΔNp73 Have Opposing Roles in 5-aza-2'-Deoxycytidine-Induced Apoptosis in Breast Cancer Cells. Mol Cells.

Katz TA et. al. (July 2014). Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 146(1):99-108.

Sakharkar AJ et. al. (June 2014). Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Int J Neuropsychopharmacol. :1-11.

Wang SC et. al. (June 2014). Antroquinonol D, Isolated from Antrodia camphorate, with DNA Demethylation and Anticancer Potential. J Agric Food Chem.

Tiao MM et. al. (April 2014). Melatonin in the Regulation of Liver Steatosis following Prenatal Glucocorticoid Exposure. Biomed Res Int. 2014:942172.

Zhang H et. al. (April 2014). Analysis of trichloroethylene-induced global DNA hypomethylation in hepatic L-02 cells by liquid chromatography-electrospray ionization tandem mass spectrometry. Biochem Biophys Res Commun. 446(2):590-5.

Xiao D et. al. (March 2014). Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats. Cardiovasc Res. 101(3):373-82.

Bielak-Zmijewska A et. al. (February 2014). A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta. Biogerontology. 15(1):47-64.

Chu M et. al. (January 2014). Androgen receptor is negatively correlated with the methylation-mediated transcriptional repression of miR-375 in human prostate cancer cells. Oncol Rep. 31(1):34-40.

Banerjee J et. al. (October 2013). A reciprocal role of prostate cancer on stromal DNA damage. Oncogene.

Perkins A et. al. (October 2013). Alcohol exposure during development: Impact on the epigenome. Int J Dev Neurosci. 31(6):391-7.

Elangovan S et. al. (October 2013). Molecular mechanism of SLC5A8 inactivation in breast cancer. Mol Cell Biol. 33(19):3920-35.

Rossi D et. al. (August 2013). Croton lechleri Müll. Arg. (Euphorbiaceae) stem bark essential oil as possible mutagen-protective food ingredient against heterocyclic amines from cooked food. Food Chem. 139(1-4):439-47.

Wu L et. al. (August 2013). Altered methylation of IGF2 DMR0 is associated with neural tube defects. Mol Cell Biochem. 380(1-2):33-42.

Chen Z et. al. (July 2013). Epigenetic regulation of cardiac progenitor cells marker c-kit by stromal cell derived factor-1α. PLoS One. 8(7):e69134.

Cho HM et. al. (July 2013). Recruitment of specificity protein 1 by CpG hypomethylation upregulates Na⁺-K⁺-2Cl⁻ cotransporter 1 in hypertensive rats. J Hypertens. 31(7):1406-13; discussion 1413.

Prasad R et. al. (July 2013). Prostaglandin E2 Promotes UV radiation-induced immune suppression through DNA hypermethylation. Neoplasia. 15(7):795-804.

Soda K et. al. (May 2013). Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis. PLoS One. 8(5):e64357.

Tong Z et. al. (May 2013). Aging-associated excess formaldehyde leads to spatial memory deficits. Sci Rep. 3:1807.

Basu N et. al. (April 2013). Effects of methylmercury on epigenetic markers in three model species: mink, chicken and yellow perch. Comp Biochem Physiol C Toxicol Pharmacol. 157(3):322-7.

HM. Cho et. al. (April 2013). Recruitment of Specificity Protein 1 by CpG hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in hypertensive rats. Journal of Hypertension. Abstract

Lomniczi A et. al. (March 2013). Epigenetic control of female puberty. Nat Neurosci. 16(3):281-9.

Liang Y et. al. (March 2013). Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin (Shanghai). 45(3):220-8.

Kano Y et. al. (February 2013). Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. PLoS One. 8(2):e56056.

Li Y et. al. (February 2013). Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer. 12:9.

Wang LS et. al. (February 2013). Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. Nutr Cancer. 65(1):118-25.

Ptak GE et. al. (February 2013). Post-implantation mortality of in vitro produced embryos is associated with DNA methyltransferase 1 dysfunction in sheep placenta. Hum Reprod. 28(2):298-305.

Sanders YY et. al. (January 2013). Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol. 1(1):8-16.

Li H et. al. (January 2013). Epigenetic regulation of CXCR4 expression by the ocular microenvironment. Invest Ophthalmol Vis Sci. 54(1):234-43.

Ma H et. al. (January 2013). Triclosan reduces the levels of global DNA methylation in HepG2 cells. Chemosphere. 90(3):1023-9.

Szemes M et. al. (January 2013). Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A. Hum Mol Genet. 22(1):74-83.

Xiong L et. al. (December 2012). DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia. FEBS J. 279(23):4318-26.

D'Costa ZJ et. al. (November 2012). Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS One. 7(11):e48954.

Du L et. al. (November 2012). Reactivation of RASSF1A in breast cancer cells by curcumin. Nutr Cancer. 64(8):1228-35.

Horiuchi A et. al. (October 2012). Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene. Int J Cancer. 131(8):1755-67.

Jiang Y et. al. (October 2012). The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice. Acta Biochim Biophys Sin (Shanghai). 44(10):866-75.

Zopf S et. al. (September 2012). Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines. BMC Cancer. 12:386.

Vaid M et. al. (August 2012). Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators. Toxicol Appl Pharmacol. 263(1):122-30.

Yamamura Y et. al. (August 2012). TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. J Cell Mol Med. 16(8):1766-75.

Jing-Bo L et. al. (August 2012). Folic acid supplementation prevents the changes in hepatic promoter methylation status and gene expression in intrauterine growth-retarded piglets during early weaning period. J Anim Physiol Anim Nutr (Berl).

Zhang Y et. al. (June 2012). Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP. Nucleic Acids Res. 40(11):4850-60.

Meeran SM et. al. (May 2012). Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One. 7(5):e37748.

Dong C et. al. (April 2012). G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest. 122(4):1469-86.

Begum G et. al. (April 2012). Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB J. 26(4):1694-703.

Fang J et. al. (January 2012). Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection. J Virol. 86(2):1010-20.

Cho HM et. al. (December 2011). Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Am J Hypertens. 24(12):1286-93.

Kodach LL et. al. (November 2011). Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. Gut. 60(11):1544-53.

Pasha Z et. al. (August 2011). Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells. PLoS One. 6(8):e23667.

Geyer KK et. al. (August 2011). Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nat Commun. 2:424.

Liu JB et. al. (August 2011). Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets. Mol Biol Rep. 38(6):3849-56.

Meeran SM et. al. (August 2011). A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev Res (Phila). 4(8):1243-54.

Nocchi L et. al. (June 2011). Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. J Biol Chem. 286(22):19478-88.

Tolg C et. al. (June 2011). Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells. Lab Invest. 91(6):825-36.

Jin Y et. al. (June 2011). Homocysteine levels impact directly on epigenetic reprogramming in astrocytes. Neurochem Int. 58(7):833-8.

Shi YY et. al. (April 2011). Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). PLoS One. 6(4):e18808.

Nandakumar V et. al. (April 2011). (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis. 32(4):537-44.

Tang B et. al. (April 2011). Interleukin-6 expression was regulated by epigenetic mechanisms in response to influenza virus infection or dsRNA treatment. Mol Immunol. 48(8):1001-8.

Nandakumar V et. al. (April 2011). Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice. Carcinogenesis. 32(4):597-604.

Yue X et. al. (March 2011). Induction of cyclooxygenase-2 expression by hepatitis B virus depends on demethylation-associated recruitment of transcription factors to the promoter. Virol J. 8:118.

Yang I et. al. (February 2011). Fused-core silica column ultra-performance liquid chromatography-ion trap tandem mass spectrometry for determination of global DNA methylation status. Anal Biochem. 409(1):138-43.

Chen W et. al. (December 2010). Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes. J Biol Chem. 285(52):40852-63.

Sui L et. al. (December 2010). Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: Role of DNA methylation and histone acetylation. Steroids. 75(12):988-97.

Li W et. al. (November 2010). IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J Immunol. 185(9):5056-65.

Montes de Oca A et. al. (September 2010). High-phosphate-induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells. J Bone Miner Res. 25(9):1996-2005.

Hicks SD et. al. (September 2010). Ethanol-induced methylation of cell cycle genes in neural stem cells. J Neurochem. 114(6):1767-80.

Skowronski K et. al. (August 2010). Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. Epigenetics. 5(6):547-56.

Pandey M et. al. (June 2010). Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. Int J Cancer. 126(11):2520-33.

Song Y et. al. (May 2010). Arabidopsis DNA methyltransferase AtDNMT2 associates with histone deacetylase AtHD2s activity. Biochem Biophys Res Commun. 396(2):187-92.

You H et. al. (May 2010). Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology. 51(5):1635-44.

Xiang H et. al. (May 2010). Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol. 28(5):516-20.

Li Y et. al. (May 2010). Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J. 24(5):1442-53.

Kastl L et. al. (April 2010). Effects of decitabine on the expression of selected endogenous control genes in human breast cancer cells. Mol Cell Probes. 24(2):87-92.

Sheikh KD et. al. (March 2010). Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft. J Med Chem. 53(6):2376-82.

Paluszczak J et. al. (February 2010). The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol Lett. 192(2):119-25.

Majid S et. al. (January 2010). Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer. 116(1):66-76.

Duthie SJ et. al. (January 2010). Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila). 3(1):92-100.

Watson JA et. al. (October 2009). Generation of an epigenetic signature by chronic hypoxia in prostate cells. Hum Mol Genet. 18(19):3594-604.

Ding L et. al. (June 2009). Camptothecin-induced cell proliferation inhibition and apoptosis enhanced by DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine. Biol Pharm Bull. 32(6):1105-8.

L. Ding et. al. (June 2009). Camptothecin-induced cell proliferation inhibition and apoptosis enhanced by DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine. Biol Pharm Bull.. 32(6):1105-8. Full PDF Article

Gaymes TJ et. al. (May 2009). Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica. 94(5):638-46.

Majid S et. al. (April 2009). BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis. 30(4):662-70.

Zampieri M et. al. (March 2009). Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity. PLoS One. 4(3):e4717.

M. Zampieri et. al. (March 2009). Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity. PLoS ONE. 4(3):e4717. Full PDF Article

Liao YJ et. al. (February 2009). Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. Int J Cancer. 124(4):816-26.

Wang X et. al. (January 2009). RAF may induce cell proliferation through hypermethylation of tumor suppressor gene promoter in gastric epithelial cells. Cancer Sci. 100(1):117-25.

Lim SO et. al. (December 2008). Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology. 135(6):2128-40, 2140.e1-8.

Guastafierro T et. al. (August 2008). CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem. 283(32):21873-80.

Suzuki M et. al. (July 2008). Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma. Mol Med Rep. 1(4):465-71.

Gravina GL et. al. (May 2008). Chronic azacitidine treatment results in differentiating effects, sensitizes against bicalutamide in androgen-independent prostate cancer cells. Prostate. 68(7):793-801.

Martínez-Chantar ML et. al. (April 2008). Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 47(4):1191-9.

M. Suzuki et. al. (March 2008). Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma. Molecular Medicine Reports. 1:465-471. Full PDF Article

Liu C et. al. (February 2008). Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr. 138(2):311-5.

Roll JD et. al. (January 2008). DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines. Mol Cancer. 7:15.

J.D. Roll et. al. (January 2008). DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines. Molecular Cancer. 7(15) Full PDF Article

Jagadeesh S et. al. (October 2007). Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells. Biochem Biophys Res Commun. 362(1):212-7.

Miyazaki T et. al. (October 2007). E-cadherin gene promoter hypermethylation in H. pylori-induced enlarged fold gastritis. Helicobacter. 12(5):523-31.

Jarosław Paluszczak et. al. (April 2007). Modulation of the activity of DNA methyltransferases by plant phenolic compounds Science24. Science24 Abstract

Liudmila Kodach et. al. (January 2007). The Role of the Bone Morphogenetic Protein Pathway in Colorectal Cancer UvA-DARE. Full PDF Article

Replace Your Santa Cruz Abs
Related Products

Researchers Also Purchased
EpiQuik Nuclear Extraction Kit
EpiQuik Nuclear Extraction Kit
EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric)
EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric)
EpiQuik HAT Activity/Inhibition Assay Kit
EpiQuik HAT Activity/Inhibition Assay Kit
Methylamp Global DNA Methylation Quantification Ultra Kit
Methylamp Global DNA Methylation Quantification Ultra Kit
Epigentek is an epigenetics company that specializes in epigenetic kits, antibodies, reagents, and services for epigenetic research in DNA methylation, histone modification, and chromatin studies. Terms & Conditions | Privacy Policy | Site Map
Copyright © 2017 Epigentek Group Inc. All rights reserved.