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Other Histone Modifications

Other Histone Modifications

Various histone modifications, such as histone citrullination and histone phosphorylation, have been shown to epigenetically impact gene expression through different mechanisms. Adjusting epigenetic marks and changing chromatin structure – known as chromatin remodeling – as a result of these histone modifications can influence gene regulation in many tissue types. Studying these histone modifications provides researchers with valuable insight into cellular processes such as apoptosis, cell growth, stress response, and transcriptional regulation.
Histone Citrullination
Histone citrullination is an epigenetic post-translational modification that converts histone arginine (Arg) to citrulline, an amino acid found in proteins, thereby impacting chromatin structure. Citrullination, which is also known as deimination, is one type of histone modification that leads to a reduction in hydrogen-bonding and a ...

Histone Phosphorylation Assay
Histone phosphorylation of histone H3 at serine 10 and serine 28 is conserved through eukaryotes, and an increase in phosphorylation has been shown to correlate with gene activation and cell growth. Detection of changes in histone phosphorylation levels can provide useful information in better understanding the pathological processes of some diseases, and for protein kinase-targeted drug developme...

SUMOylation is a post-translational modification that plays a role in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle. Small Ubiquitin-like Modifier (SUMO) proteins are attached to and detached from other proteins in cells to alter their function. The detection of in vivo protein SUMOylation (SUMO conjugation) would provide useful informati...

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