Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
HDAC3 Monoclonal Antibody [A10B1]. Unconjugated. Raised in: Mouse.
Liquid. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3..
Recombinant Protein of Human HDAC3
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
HD 3 antibody, histone deacetylase 3 antibody, RPD 3 antibody, RPD3 2 antibody, SMAP 45 antibody, SMAP45 antibody
WB, ICC; Recommended dilution: WB (1:500 - 1:2000); ICC (1:200 - 1:500)