HDAC3 Monoclonal Antibody [A10B1]

Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Description
HDAC3 Monoclonal Antibody [A10B1]. Unconjugated. Raised in: Mouse, Clone A10B1.

Formulation
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Human, Mouse, Rat

Isotype
IgG

Uniprot ID
O15379

Purification
Affinity Purification

Immunogen
Recombinant protein of human HDAC3

Storage
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Alternative Names
HD 3 antibody, histone deacetylase 3 antibody, RPD 3 antibody, RPD3 2 antibody, SMAP 45 antibody, SMAP45 antibody

Application
WB, ICC; Recommended dilution: WB: 1:500-1:2000, ICC1:200-1:500