Browse practical epigenetics articles, application notes, and research resources organized by topic. Use search to quickly locate guidance relevant to your workflow.
Lin R et. al. (April 2025). CPK27 enhances cold tolerance by promoting flavonoid biosynthesis through phosphorylating HY5 in tomato New Phytol. This study investigates the role of Calcium-dependent protein...
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Nimal S et. al. (April 2025). Reversal of epithelial to mesenchymal transition in triple negative breast cancer through epigenetic modulations by dietary flavonoid Galangin and its combination with SAHA Cell...
Read articleAfroze N et. al. (April 2025). Kaempferol Targets Global Epigenetic Modifiers to Impedes Growth and Migratory Ability of HeLa Cells J Cell Mol Med. 29(7):e70498. This study investigates the epigenetic...
Read articleLiu L et. al. (March 2025). Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos Mol Med. 31(1):95. This study investigates the role of the...
Read articleLiu L et. al. (March 2025). Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos Mol Med. 31(1):95. This study investigates the role of the...
Read articleLiao M et. al. (March 2025). HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability Cancer Cell Int. 25(1):85. This study investigates the role of HNRNPC in promoting...
Read articleWang J et. al. (February 2025). Targeted Delivery of α-ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes Adv Sci (Weinh). :e2415667. This...
Read articleChang K et. al. (February 2025). FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism Chang K et....
Read articlePalczewski MB et. al. (February 2025). Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome Nat Commun. 16(1):1732. This study investigates how nitric...
Read articleYang C et. al. (February 2025). The Diminution of R-Loops Generated by LncRNA DSP-AS1 Inhibits DSP Gene Transcription to Impede the Re-Epithelialization During Diabetic Wound Healing Adv Sci...
Read articleUlhe A et. al. (February 2025). Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines Epigenetics. 20(1):2451551. This study investigates the epigenetic effects of...
Read articleZhao S et. al. (January 2025). TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6 J Biol Chem. :108228. This study investigates the role of TET1 in...
Read articleYu Z et. al. (January 2025). TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma Clin Epigenetics. 17(1):10. This study investigates the role...
Read articleZhang N et. al. (January 2025). RNA m6A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells Cell Death Discov. 11(1):4. This study investigates the...
Read articleHaidar M et. al. (January 2025). Defining epitranscriptomic hallmarks at the host-parasite interface and their roles in virulence and disease progression in Theileria annulata-infected leukocytes Biomed...
Read articleCong P et. al. (December 2024). DNMT3a Deficiency Contributes to Anesthesia/Surgery-Induced Synaptic Dysfunction and Cognitive Impairment in Aged Mice Aging Cell. :e14458. This study investigates the role...
Read articleCobo-Vuilleumier N et. al. (December 2024). LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype Clin Transl...
Read articleCasarotto LT et. al. (December 2024). Late-gestation heat stress alters placental structure and function in multiparous dairy cows J Dairy Sci. This study investigates the effects of late-gestation heat...
Read articleWang Y et. al. (December 2024). The m6A demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification Cardiovasc Res. This study investigates the role of ALKBH5, an m6A RNA demethylase, in...
Read articleYung WS et. al. (November 2024). DNA Hypomethylation Is One of the Epigenetic Mechanisms Involved in Salt-Stress Priming in Soybean Seedlings Yung WS et. al. (November 2024). This study investigates how...
Read articleZhang X et. al. (November 2024). RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells Zhang X et. al. (November 2024). This study investigates the role of RNA m6A...
Read articleYang Y et. al. (November 2024). Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer Nat Cancer. This study identifies...
Read articleJia Y et. al. (November 2024). Induction of FAM46C expression mediated by DNMT3A downregulation is involved in early-onset preeclampsia through gene body methylation Cell Signal. :111506. This study...
Read articlePandya RK et. al. (December 2024). Global DNA methylation level in spermatozoa is not associated with ICSI fertilization outcome and embryo quality in donor oocyte programme Hum Fertil...
Read articleMo A et. al. (October 2024). WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer Biomark Med. :1-11. This study shows that WTAP, which is...
Read articleMo A et. al. (October 2024). WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer Biomark Med. :1-11. This study shows that WTAP, which is...
Read articleRahman MM et. al. (October 2024). dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation Eur J Cell Biol. 103(4):151463. This study investigates the use of a...
Read articleRoychaudhuri R et. al. (October 2024). Mammalian D-Cysteine controls insulin secretion in the pancreas Mol Metab. :102043. This study identifies D-cysteine in the mammalian pancreas as a regulator of...
Read articleShi X et. al. (October 2024). N6-methyladenosine-mediated upregulation of LNCAROD confers radioresistance in esophageal squamous cell carcinoma through stabilizing PARP1 Shi X et. al. (October 2024). This...
Read articleSantos J et. al. (September 2024). LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects Antioxidants...
Read articleDiNardo CD et. al. (September 2024). Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses Nat Cancer. This study examines...
Read articleGuan Y et. al. (September 2024). The effect of nitrosative stress on histone H3 and H4 acetylation in Phytophthora infestans life cycle Plant Physiol Biochem. 216:109129. This study investigates how...
Read articleChen Y et. al. (September 2024). WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury Int J Surg. 110(9):5396-5408. This study...
Read articleNegi CK et. al. (September 2024). Triphenyl Phosphate Alters Methyltransferase Expression and Induces Genome-Wide Aberrant DNA Methylation in Zebrafish Larvae Chem Res Toxicol. 37(9):1549-1561. This study...
Read articleMittal P et. al. (August 2024). PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression Nat Commun. 15(1):7303. This study examines how PHF6 collaborates with SWI/SNF chromatin...
Read articleZhao L et. al. (August 2024). N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus PLoS...
Read articleOh SY et. al. (August 2024). Chromatin remodeling-driven autophagy activation induces cisplatin resistance in oral squamous cell carcinoma Cell Death Dis. 15(8):589. This study explores how chromatin...
Read articleKumar P et. al. (August 2024). Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice FASEB J. 38(15):e23858. This study investigates how...
Read articleGan Y et. al. (July 2024). The Role of Oxidative Stress and DNA Hydroxymethylation in the Pathogenesis of Benzo[a]pyrene-Impaired Reproductive Function in Male Mice Environ Toxicol. This study examines the...
Read articleAngelin M et. al. (July 2024). Global DNA and RNA Methylation Signature in Response to Antipsychotic Treatment in First-Episode Schizophrenia Patients Neuropsychiatr Dis Treat. 20:1435-1444. This study...
Read articleIriondo O et. al. (July 2024). Hypoxic Memory Mediates Prolonged Tumor Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Cancer Res. This study investigates how hypoxia induces a...
Read articleAdams-Sherrod GA et. al. (July 2024). Sex-specific modulation of renal epigenetic and injury markers in aging kidney Am J Physiol Renal Physiol. This study examines how sex and age affect kidney epigenetic...
Read articleOga K et. al. (June 2024). Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction Psychopharmacology (Berl). This study explores how...
Read articleCrosswhite P et. al. (May 2024). TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation Antioxidants (Basel). 13(6)...
Read articleWang R et. al. (June 2024). TET1 Regulates Nestin Expression and Human Airway Smooth Muscle Proliferation Am J Respir Cell Mol Biol. This study investigates the role of TET1 in regulating nestin expression...
Read articleGu T et. al. (June 2024). METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla Exp Mol Med. This study explored the role of METTL3 in...
Read articleGu T et. al. (June 2024). METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla Exp Mol Med. This study explored the role of METTL3 in...
Read articleWu X et. al. (May 2024). Endothelial cell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS Cell Commun Signal. 22(1):293. This...
Read articleLiu Y et. al. (May 2024). DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma Mol Cancer. 23(1):104. This study...
Read articleFeng X et. al. (April 2024). Heat-Stress Impacts on Developing Bovine Oocytes: Unraveling Epigenetic Changes, Oxidative Stress, and Developmental Resilience Int J Mol Sci. 25(9) The study investigated the...
Read articleShi F et. al. (May 2024). Epstein-Barr virus-driven metabolic alterations contribute to the viral lytic reactivation and tumor progression in nasopharyngeal carcinoma J Med Virol. 96(5):e29634. This study...
Read articleNimal S et. al. (April 2024). Apigenin and its combination with Vorinostat induces apoptotic-mediated cell death in TNBC by modulating the epigenetic and apoptotic regulators and related miRNAs Sci...
Read articleFeng L et. al. (September 2024). ALKBH5 regulates arginase 1 expression in MDSCs and their immunosuppressive activity in tumor-bearing host Noncoding RNA Res. 9(3):913-920. This study investigates the role...
Read articleJeffrey MP et. al. (April 2024). A Lacticaseibacillus rhamnosus secretome induces immunoregulatory transcriptional, functional and immunometabolic signatures in human THP-1 monocytes Sci Rep. 14(1):8379. In...
Read articleMennitti LV et. al. (April 2024). Maternal dietary fatty acid composition and content prior to and during pregnancy and lactation influences serum profile, liver phenotype and hepatic miRNA expression in...
Read articleWang S et. al. (April 2024). DNA methylation regulates the secondary metabolism of saponins to improve the adaptability of Eleutherococcus senticosus during drought stress BMC Genomics. 25(1):330. The...
Read articleMalaviya P et. al. (February 2024). Diabetic Retinopathy and Regulation of Mitochondrial Glutathione-Glutathione Peroxidase Axis in Hyperhomocysteinemia Antioxidants (Basel). 13(3) The article explores how...
Read articleLoeb EJ et. al. (March 2024). Capsid-mediated control of adeno-associated viral transcription determines host range Cell Rep. 43(3):113902. This study demonstrates that the capsid of adeno-associated...
Read articleWang J et. al. (March 2024). Natural variation in BnaA9.NF-YA7 contributes to drought tolerance in Brassica napus L Nat Commun. 15(1):2082. The study identifies a transcription factor, BnaA9.NF-YA7, in...
Read articleLoeb EJ et. al. (March 2024). Capsid-mediated control of adeno-associated viral transcription determines host range Cell Rep. 43(3):113902. The study investigated the mechanisms by which the capsid of...
Read articleDu Y et. al. (February 2024). Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry New Phytol. This study delves into the intricate regulation of flavonoid...
Read articleLu X et. al. (February 2024). High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes...
Read articleSong Y et. al. (February 2024). Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming Sci Adv. 10(7):eadk0639. The study examines how matrix stiffness impacts chromatin...
Read articlePirola CJ et. al. (February 2024). Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease EBioMedicine. 101:104996. The article...
Read articleKang YY et. al. (January 2024). Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury Adv Sci (Weinh). :e2308978. In this study, researchers investigated the impact of systemic...
Read articleAlghamdi AA et. al. (January 2024). Alterations in Histone Methylation States Increased Profusion of Lethal(2)-Essential-for-Life-Like (l(2)elf), Trithorax and Polycomb Genes in Apis mellifera under Heat...
Read articleFeng P et. al. (February 2024). Enhancer-mediated FOXO3 expression promotes MSC adipogenic differentiation by activating autophagy Biochim Biophys Acta Mol Basis Dis. 1870(2):166975. This study investigates...
Read articleKang SH et. al. (January 2024). Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p...
Read articleHe S et. al. (December 2023). NtERF4 promotes the biosynthesis of chlorogenic acid and flavonoids by targeting PAL genes in Nicotiana tabacum Planta. 259(2):31. In this study, researchers found that NtERF4a...
Read articleZhang Y et. al. (December 2023). Histone H3 Acetylation Is Involved in Retinoid Acid-Induced Neural Differentiation through Increasing Mitochondrial Function Biomedicines. 11(12) This study, using the...
Read articleRidany I et. al. (December 2023). Aromatic Hydrocarbon Receptor Repressor (AHRR) Is a Biomarker of Ambient Air Pollution Exposure and Coronary Artery Disease (CAD) Environ Toxicol Pharmacol. :104344. In a...
Read articleQiu B et. al. (December 2023). Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms J Cosmet Dermatol. This study explores the role of SPRY1 and TET3 in natural skin aging,...
Read articleHaider N et. al. (November 2023). Interactions between insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts J Clin Invest. This study investigated how...
Read articleWang J et. al. (November 2023). HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification Cell Death Discov. 9(1):411. In the study,...
Read articleKmiołek T et. al. (November 2023). Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome Immun Ageing. 20(1):61. This study...
Read articleLiu Z et. al. (November 2023). DNA methylation on C5-Cytosine and N6-Adenine in the Bursaphelenchus xylophilus genome BMC Genomics. 24(1):671. This study explores the epigenetic modifications in the genome...
Read articleWang T et. al. (October 2023). Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1 Pathway Am J Chin Med. :1-20. The article investigates the role of Wogonin (WG), a...
Read articleSun Y et. al. (October 2023). Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE) Environ Sci Technol. The study...
Read articleZhang L et. al. (October 2023). Acetyltransferases CBP/p300 control transcriptional switch of β-catenin and Stat1 promoting osteoblast differentiation J Bone Miner Res. The article explores the role of...
Read articleMartínez-Iglesias O et. al. (August 2023). Influence of Metabolic, Transporter, and Pathogenic Genes on Pharmacogenetics and DNA Methylation in Neurological Disorders Biology (Basel). 12(9) This study...
Read articlePark K et. al. (October 2023). Bioaccumulation, microbiome composition and immunity, and epigenetic signatures associated with exposure to spherical, fibrous, and fragmented microplastics in the mussel...
Read articleZhang Y et. al. (October 2023). Knocking down a DNA demethylase gene affects potato plant defense against a specialist insect herbivore J Exp Bot. This study aimed to understand the role of DNA demethylase...
Read articleRamírez-Tejero JA et. al. (July 2020). Epigenetic Regulation of Verticillium dahliae Virulence: Does DNA Methylation Level Play A Role? Int J Mol Sci. 21(15) This article investigates the role of...
Read articleWu M et. al. (September 2023). TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation Respir Res. 24(1):222. This article investigates the mechanisms behind...
Read articleMay MA et. al. (September 2023). Uncovering the roles of sirtuin activity and food availability during the onset of the heat shock response in the California mussel (Mytilus californianus): Implications for...
Read articlePiro MC et. al. (July 2023). In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis Int J Mol Sci. 24(15) This study investigates the role of specific histone modifications,...
Read articleConvertini P et. al. (August 2023). ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis J Transl Med. 21(1):568. This study explores the role of the...
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Aggarwal A et. al. (August 2023). Disruption of histone acetylation homeostasis triggers cognitive dysfunction in experimental diabetes Neurochem Int. :105592. The study investigates the impact of disrupted...
Read articleKiran GS et. al. (August 2023). Unravelling blood-based epigenetic mechanisms: the impact of hsa-miR-146a and histone H3 acetylation in lead-induced inflammation among occupational workers Int Arch Occup...
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Padalino G et. al. (March 2023). Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes Wellcome Open Res. 8:146. The...
Read articleQu K et. al. (September 2023). Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization APL Bioeng. 7(3):036104. In...
Read articleBazan N et. al. (July 2023). Elovanoids are neural resiliency epigenomic regulators targeting histone modifications, DNA methylation, tau phosphorylation, telomere integrity, senescence programming, and...
Read articleArchilia EC et. al. (July 2023). Effects of follicle-stimulating hormone, insulin-like growth factor 1, fibroblast growth factor 2, and fibroblast growth factor 9 on sirtuins expression and histone...
Read articleTangili M et. al. (July 2023). DNA methylation markers of age(ing) in non-model animals Mol Ecol. In this article, researchers investigated the development of epigenetic clocks based on DNA methylation in...
Read articleSoto J et. al. (June 2023). Reduction of Intracellular Tension and Cell Adhesion Promotes Open Chromatin Structure and Enhances Cell Reprogramming Adv Sci (Weinh). :e2300152. In this study, researchers...
Read articleWang X et. al. (June 2023). METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing Transl Med. 21(1):407. The study explores the role of...
Read articleLiang E et. al. (June 2023). M6A modification promotes blood-brain barrier breakdown during cerebral ischemia/reperfusion injury through increasing matrix metalloproteinase 3 expression...
Read articleHuang L et. al. (December 2023). WTAP regulates autophagy in colon cancer cells by inhibiting FLNA through N6-methyladenosine Cell Adh Migr. 17(1):1-13. This study explores the role of WTAP in colon cancer...
Read articleLi J et. al. (June 2023). The role of m6A methylation in prenatal maternal psychological distress and birth outcome. J Affect Disord. This prospective cohort study investigated the relationships between...
Read articleZhou Y et. al. (May 2023). Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice Ecotoxicol Environ Saf. 260:115072. This study investigated the effect of prenatal...
Read articleNie G et. al. (May 2023). HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition Cell Biol Int. This study investigates the...
Read articleKim J et. al. (May 2023). Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide. Ecotoxicol Environ Saf. 258:114967....
Read articleLi S et. al. (May 2023). Paternal combined botanicals contribute to the prevention of estrogen receptor-negative mammary cancer in transgenic mice. J Nutr. In this study, the researchers aimed to investigate...
Read articleKim J et. al. (April 2023). Trans- and Multigenerational Effects of Isothiazolinone Biocide CMIT/MIT on Genotoxicity and Epigenotoxicity in Daphnia magna. Toxics. 11(4) The study evaluated the toxicity of...
Read articleFang Z et. al. (April 2023). Integrated analysis based on vesicle trafficking-related genes identifying CNIH4 as a novel therapeutic target for glioma. Cancer Med. The study identified Cornichon family AMPA...
Read articleKong X et. al. (April 2023). Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing. PBRM1 affect bovine sperm structure and motility. Nat Commun....
Read articleAlattal YZ et. al. (February 2023). Linking Histone Methylation States and hsp Transcriptional Regulation in Thermo-Tolerant and Thermo-Susceptible A. mellifera L. Subspecies in Response to Heat Stress....
Read articleYin S et. al. (March 2023). CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep. 42(4):112316. The paper investigates the role of CDK5-PRMT1-WDR24 signaling cascade in...
Read articleLee BB et. al. (March 2023). Metformin regulates expression of DNA methyltransferases through the miR-148/-152 family in non-small lung cancer cells. Clin Epigenetics. 15(1):48. The paper explores how the...
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