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Kong X et. al. (April 2023).
Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range
for genome editing.
PBRM1 affect bovine sperm structure and motility.
Nat Commun.
14(1):2046.
The study explored the identification and engineering of six uncharacterized Cas12f1 proteins
with nuclease activity in mammalian cells, which showed high editing activity and broad PAMs.
The researchers demonstrated the potential of these engineered Cas12f1 variants for gene editing
and epigenetic editing in mammalian cells, with implications for therapeutic applications.
(Products Used:
BisulFlash DNA Modification Kit)
Draghici GA et. al. (April 2023).
Cadmium nitrate and DNA methylation in gastropods: comparison between ovotestis
and hepatopancreas.
PeerJ.
11:e15032.
This article explores the effects of dietary cadmium on the DNA methylation patterns in the
common brown garden snail, Cornu aspersum. The study found that exposure to
environmentally-relevant levels of cadmium resulted in a reduction in body weight and
an increase in hypometabolic behavior, while the hepatopancreas displayed significant
hypermethylation but not the ovotestis, and the methylation status of the Cd-MT gene was
insensitive to cadmium exposure.
(Products Used:
MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric))
Yang S et. al. (April 2023).
OsUGE1 is directly targeted by OsGRF6 to regulate root hair length in rice.
Theor Appl Genet.
136(5):108.
In this article, researchers investigate the role of OsUGE1 and OsGRF6 in regulating
root hair elongation in rice. They found that OsUGE1 negatively regulates root hair
elongation and is directly targeted by OsGRF6, which binds to its promoter, and that
knockout mutants of OsGRF6 have shorter root hairs, suggesting a novel pathway for
controlling root hair length in rice.
(Products Used:
EpiQuik Plant ChIP Kit)
Wang X et. al. (March 2023).
YTHDC2-mediated m6A mRNA modification of Id3 suppresses cisplatin
resistance in non-small cell lung cancer.
J Thorac Dis.
15(3):1247-1257.
In this article, the authors investigated the role of YTHDC2-mediated m6A mRNA modification
of Id3 in controlling cisplatin resistance in non-small cell lung cancer (NSCLC). The study
found that YTHDC2 requires modifications to m6A to inhibit cisplatin resistance in NSCLC by
regulating the activity of Id3
(Products Used:
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Fang Q et. al. (April 2023).
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells
by activating the IκB-NF-κB-CCND1 axis.
Cell Rep.
42(4):112403.
In this study, researchers demonstrated that the liquid-liquid phase separation of
YTHDF1 protein triggers the transition of spermatogonial stem cells into neural stem
cell-like cells by activating the IκB-NF-κB-CCND1 axis through the inhibition of
IκBα/β mRNA translation. These findings provide new insights into the role of
protein-RNA LLPS in cell fate transition and its potential applications in
translational medicine and neurological disease therapy.
(Products Used:
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Li S et. al. (April 2023).
Integrated analysis of transcriptome-wide m(6)A methylation
in a Cd-induced kidney injury rat model.
Ecotoxicol Environ Saf.
256:114903.
This article presents a study on the role of N6-methyladenosine (m6A) in CdCl2-induced kidney injury in
rats.
The study found that m6A levels and regulators were increased in CdCl2-treated rats, and identified
differentially expressed genes and pathways related to inflammation and metabolism, as well as top hub
genes potentially involved in CdCl2-induced kidney damage.
(Products Used:
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Guan J et. al. (April 2023).
Critical role of transcriptome-wide m6A methylation in the aqueous
humor of patients with pseudoexfoliation glaucoma.
Exp Eye Res.
:109473.
The article investigates the role of N6-methyladenosine (m6A) modification in
pseudoexfoliation glaucoma (PXG) by analyzing the m6A methylome in the aqueous
humor of patients. Results indicate that m6A plays a critical role in extracellular
matrix formation and histone deacetylation in PXG, and that METTL3 may be a pivotal
regulator of this process.
(Products Used:
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Zheng C et. al. (April 2023).
The deficiency of N6-methyladenosine demethylase ALKBH5 enhances the
neurodegenerative damage induced by cobalt.
Sci Total Environ.
:163429.
The article discusses the role of the m6A demethylase ALKBH5 in cobalt-induced
neurodegenerative damage and proposes it as a potential therapeutic target. The study
shows that ALKBH5 deficiency exacerbates cell damage induced by cobalt and that the
differentially modified genes resulting from ALKBH5 downregulation and cobalt exposure
are involved in pathways of proliferation, apoptosis, and autophagy.
(Products Used:
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Zhong D et. al. (April 2023).
Comprehensive analysis of long non-coding RNA expression
profiles of GC-1spg cells with m6A methylation knockdown.
Gene.
:147430.
The study investigates the relationship between m6A methylation and
lncRNAs in spermatogenesis by knocking down METTL3 in GC-1spg cells and examining the lncRNA expression
profiles of normal spermatogonia and those with knocked down METTL3. The study identifies three lncRNAs
that are regulated by METTL3 and may act as miRNA sponges to regulate genes related to spermatogenesis.
(Products Used:
EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit)
