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Archilia EC et. al. (July 2023). Effects of follicle-stimulating hormone, insulin-like growth factor 1, fibroblast growth factor 2, and fibroblast growth factor 9 on sirtuins expression and histone deacetylase activity in bovine granulosa cells Theriogenology. 210:1-8.
This study focuses on the effects of various hormones on the expression of sirtuins and histone deacetylase activity in bovine granulosa cells, which play a crucial role in folliculogenesis and fertility. The study found that follicle-stimulating hormone (FSH) and insulin-like growth factor 1 (IGF-1) promote cell proliferation, while fibroblast growth factors 2 (FGF2) and 9 (FGF9) have significant impacts on sirtuins expression, suggesting that sirtuins may be associated with the differentiation of bovine granulosa cells.
Products Used: Epigenase Universal SIRT Activity/Inhibition Assay Kit (Colorimetric)
Zheng Z et. al. (June 2023). Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway J Pharm Anal. 13(6):590-602.
The study investigated the therapeutic potential of inhibiting PRMT5 in cisplatin-induced hearing loss. Inhibition of PRMT5 attenuated cisplatin-induced damage to cochlear hair cells and spiral ganglion neurons, decreased apoptosis through protection of mitochondrial function, and prevented the accumulation of reactive oxygen species, suggesting that PRMT5 inhibitors could be potential agents against cisplatin-induced ototoxicity through the PI3K/Akt-mediated mitochondrial apoptotic pathway.
Products Used: Histone H3R8 Dimethyl Symmetric (H3R8me2s) Polyclonal Antibody
Shao J et. al. (July 2023). MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat Toxicol Lett.
The study investigates the regulatory mechanism of the voltage-gated sodium channel subtype Nav1.6 in oxaliplatin-induced neuropathic pain in rats. The findings suggest that the MAPK-ERK-CREB signaling pathway is involved in the upregulation of Nav1.6, enhancing neuronal excitability and contributing to neuropathic pain in response to oxaliplatin treatment.
Products Used: EpiQuik Chromatin Immunoprecipitation (ChIP) Kit
Cao M et. al. (July 2023). The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes Mediterr J Hematol Infect Dis. 15(1):e2023040.
The article focuses on the mechanism of miR-155-5p in myelodysplastic syndromes (MDS) and its impact on CD34+ cells. The research shows that miR-155-5p upregulation in MDS patients contributes to CD34+ cell apoptosis by inhibiting RAC1/CREB/miR-15b axis, leading to impaired bone marrow hematopoiesis. Additionally, miR-155-5p also induces the expression of PD-L1, which further affects CD34+ cell apoptosis in MDS.
Products Used: ChromaFlash High-Sensitivity ChIP Kit
Archilia EC et. al. (July 2023). Effects of follicle-stimulating hormone, insulin-like growth factor 1, fibroblast growth factor 2, and fibroblast growth factor 9 on sirtuins expression and histone deacetylase activity in bovine granulosa cells Theriogenology. 210:1-8.
The study investigates the effects of follicle-stimulating hormone (FSH), insulin-like growth factor 1 (IGF-1), fibroblast growth factor 2 (FGF2), and fibroblast growth factor 9 (FGF9) on the expression of sirtuins and histone deacetylase activity in bovine granulosa cells (GC) during ovarian folliculogenesis. The results show that FGF2 and FGF9 have significant impacts on the expression of sirtuins and histone deacetylase activity, suggesting their association with the regulation of GC differentiation and proliferation.
Products Used: EpiQuik Nuclear Extraction Kit
Lei Y et. al. (July 2023). Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei J Hazard Mater. 458:131996.
The study investigates the N6-methyladenosine (m6A) RNA methylation landscapes induced by toxic ammonia exposure in the Pacific whiteleg shrimp Litopenaeus vannamei. The results reveal dynamic changes in m6A methylation levels and the involvement of m6A methylation in regulating genes associated with metabolism, immune defense, and apoptotic signaling pathways in response to ammonia stress in shrimp.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Xiao H et. al. (June 2023). Effects and translatomics characteristics of a small-molecule inhibitor of METTL3 against non-small cell lung cancer J Pharm Anal. 13(6):625-639.
The article evaluates the efficacy of the small-molecule inhibitor STM2457 against non-small cell lung cancer (NSCLC) by inhibiting METTL3, a protein involved in translation regulation and PD-L1 expression. STM2457 shows potential as a suppressor of tumor progression, overcoming heterogeneity, and improving immunotherapy outcomes in NSCLC through its impact on the translatome and PD-L1 upregulation.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Li J et. al. (July 2023). Analysis of N6-methyladenosine reveals a new important mechanism regulating the salt tolerance of sugar beet (Beta vulgaris) Plant Sci. :111794.
The article investigates the role of N6-methyladenosine (m6A) in regulating salt tolerance in sugar beets (Beta vulgaris). The study identifies significantly modified m6A sites and differentially expressed genes (DEGs) under salt stress and reveals a negative correlation between m6A modification and gene expression, suggesting that m6A modification may regulate salt-tolerant genes by controlling mRNA stability through the demethylase BvAlkbh10B, providing insights into the epigenetic mechanisms of salt tolerance in sugar beets.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Zhang Z et. al. (July 2023). The rs1421085 variant within FTO promotes brown fat thermogenesis Nat Metab.
The study investigates the functional role of the rs1421085 T>C variant within the FTO gene, a genetic risk signal for obesity. The study demonstrates that the C-allele of rs1421085 enhances brown fat thermogenic capacity and confers resistance to high-fat diet-induced adiposity in mice, indicating that this variant promotes brown fat thermogenesis by enhancing the transcription of the FTO gene in brown adipocytes.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
