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Haidar M et. al. (January 2025). Defining epitranscriptomic hallmarks at the host-parasite interface and their roles in virulence and disease progression in Theileria annulata-infected leukocytes Biomed J. :100828.
This study investigates the role of m6A RNA modification in the transformation of bovine leukocytes infected by Theileria annulata. Through m6A sequencing and bioinformatics analysis, the researchers identified specific mRNA modifications linked to increased leukocyte proliferation, potentially mediated by E2F4 and HIF-1α. These findings highlight m6A methylation as a key factor in host-parasite interactions, influencing virulence and disease progression.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Zhuang Y et. al. (January 2025). ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma Sci Rep. 15(1):1514.
This study explores the role of ALKBH5, an m6A RNA demethylase, in the growth and metastasis of papillary thyroid carcinoma (PTC). Analysis of patient tissues and PTC cell lines revealed that ALKBH5 expression was lower in cancerous tissues and negatively correlated with tumor proliferation and invasion. Overexpression of ALKBH5 reduced tumor cell viability and metastasis, suggesting that targeting m6A modification through ALKBH5 could be a potential therapeutic strategy for PTC.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Zhou C et. al. (January 2025). WTAP/IGF2BP3 Mediated m6A Modification of SOD2 mRNA Aggravates the Tumourigenesis of Colorectal Cancer J Biochem Mol Toxicol. 39(1):e70117.
This study examines the role of WTAP, an m6A regulatory protein, in the progression of colorectal cancer (CRC). WTAP was highly expressed in CRC tissues and cell lines, where it promoted tumor growth by stabilizing SOD2 mRNA through m6A modification in an IGF2BP3-dependent manner. Silencing WTAP suppressed CRC progression, suggesting that targeting the WTAP-SOD2 axis could be a potential therapeutic strategy for CRC.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Maran SR et. al. (January 2025). Leishmania mexicana N-Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression Mol Microbiol. 123(1):60-74.
This study investigates the role of N-acetyltransferase 10 (NAT10) in Leishmania mexicana, highlighting its importance in polysome formation and cell cycle progression. The researchers found that LmexNAT10 is nuclear and essential for parasite survival, influencing multiplication, differentiation, and protein synthesis. These findings suggest that LmexNAT10 may regulate RNA modifications, impacting parasite adaptation and development.
Products Used: EpiQuik HAT Activity/Inhibition Assay Kit
