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Wang X et. al. (June 2023). METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing Transl Med. 21(1):407.
The study explores the role of METTL3-mediated m6A modification in endometriosis. Decreased METTL3 expression leads to reduced m6A RNA methylation levels, promoting the viability, proliferation, migration, and invasion of endometrial stromal cells (ESCs) through the METTL3-YTHDF2-SIRT1/FOXO3a axis, ultimately contributing to the progression of endometriosis.
(Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Xiao Z et. al. (June 2023). METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells Cell Rep. 42(7):112684.
The study reveals that METTL3-mediated m6A methylation plays a crucial role in regulating the functional specification of γδ T17 and γδ T1 cells. By controlling mRNA stability and preventing the formation of endogenous double-stranded RNAs, METTL3-mediated m6A methylation balances the activation of STAT1 signaling, thus maintaining the equilibrium between γδ T17 and γδ T1 cells.
(Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Zhou J et. al. (June 2023). Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin Mol Biol Rep.
The study investigates the role of N6-methyladenosine (m6A) mRNA methylation in unconjugated bilirubin (UCB) neurotoxicity using PC12 cells. The results show that UCB treatment alters the expression of m6A demethylases and methyltransferases, leading to changes in total m6A levels and differential m6A peaks in genes associated with protein processing, ubiquitin-mediated proteolysis, cell cycle, and endocytosis, highlighting the significance of m6A methylation in UCB-induced neurotoxicity.
(Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Miyake K et. al. (June 2023). A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth Cell Rep. 42(7):112688.
The study investigated the impact of the cancer-associated METTL14 R298P mutation on m6A modification and tumor growth. The mutation was found to disrupt normal m6A modification patterns, leading to aberrant modification at non-canonical motifs and altered methylation efficiency at canonical motifs. This resulted in destabilization of c-MET mRNA, reduced c-Myc expression, and suppressed cell proliferation, highlighting the significance of the METTL14 mutation in perturbing gene expression patterns and tumor development.
(Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric))
Bredel M et. al. (June 2023). Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas Cell Rep Med. 4(6):101082.
In this article, the study reveals that haploinsufficient deletions of the tumor suppressor NFKB inhibitor alpha (NFKBIA) exhibit unique occurrence patterns and are associated with unfavorable outcomes and increased recurrence in diffuse gliomas. NFKBIA deletions reshape the DNA and histone methylome, resulting in transcriptome changes resembling H3K27M mutant pediatric gliomas, and predict comparatively short survival in IDH mutant gliomas, highlighting the significance of NFKBIA haploinsufficiency in determining disease fate and the need for its inclusion in prognostic models for diffuse gliomas.
(Products Used: EpiQuik Global Histone H3K27 Methylation Assay Kit)
Lucky AB et. al. (June 2023). A type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum Commun Biol. 6(1):659.
The study focuses on PfPRMT5, a protein arginine methyltransferase in Plasmodium falciparum, and reveals its essential role in regulating merozoite invasion in the malaria parasite. Disruption of PfPRMT5 results in growth defects and reduced invasion efficiency, accompanied by down-regulation of invasion-related transcripts and anomalies in RNA splicing events, highlighting the critical involvement of PfPRMT5 in invasion and RNA processing in P. falciparum.
(Products Used: Histone H3R2 Dimethyl Symmetric (H3R2me2s) Polyclonal Antibody, Histone H3R2 Dimethyl Asymmetric (H3R2me2a) Polyclonal Antibody)
Boovarahan SR et. al. (June 2023). CABG Patients Develop Global DNA Hypermethylation, That Negatively Affect the Mitochondrial Function and Promote Post-Surgical Cognitive Decline: A Proof of Concept in Small Cohort J Clin Med. 12(12)
This study demonstrated a connection between global DNA hypermethylation, mitochondrial dysfunction, and cognitive decline in patients after coronary artery bypass grafting (CABG) surgery. The findings suggest that increased DNA methylation and impaired mitochondrial function are associated with post-surgical cognitive decline, highlighting the potential for using multimarker approaches to identify at-risk individuals.
(Products Used: MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric))
Wu J et. al. (June 2023). Nuclear translocation of OsMADS25 facilitated by OsNAR2.1 in response to nitrate signal promotes root growth by regulating the expression of OsMADS27 and OsARF7 in rice Plant Commun. :100642.
In this study, the researchers aimed to investigate the mechanism behind the nuclear translocation of OsMADS25 and its role in promoting root growth in response to nitrate signals. They discovered that OsMADS25 moves from the cytoplasm to the nucleus in the presence of nitrate, facilitated by OsNAR2.1, and subsequently activates the expression of OsMADS27 and OsARF7, leading to enhanced root growth.
(Products Used: ChromaFlash Plant Chromatin Extraction Kit)
