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Piro MC et. al. (July 2023). In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis Int J Mol Sci. 24(15)
This study investigates the role of specific histone modifications, H3K9me2 and H3K79me3, as epigenetic barriers against cancer development. The study's findings, as indicated in the abstract, highlight these histone modifications as potential protective factors against carcinogenesis, shedding light on their significance in cancer prevention and therapy.
Products Used: Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody, Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody, Histone H3K79me2 (H3K79 Dimethyl) Polyclonal Antibody, Histone H3K79me3 (H3K79 Trimethyl) Polyclonal Antibody, EpiQuik Total Histone Extraction Kit, MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric), EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric)
Zhao Z et. al. (July 2023). Host DNA Demethylation Induced by DNMT1 Inhibition Up-Regulates Antiviral OASL Protein during Influenza a Virus Infection Viruses. 15(8)
The article explores the mechanisms of influenza A virus (IAV) infection on host DNA methylation and gene expression. The study reveals that during IAV infection, suppression of DNMT1 expression through miR-142-5p or the PI3K/AKT signaling pathway leads to DNA demethylation of the OASL promoter region, resulting in increased OASL protein expression. This upregulation of OASL enhances the host's antiviral response and inhibits IAV replication, shedding light on an innate immunity mechanism involving epigenetic modifications during viral infections.
Products Used: EpiQuik Nuclear Extraction Kit, EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric)
Yang Z et. al. (September 2023). Reducing branched-chain amino acids improves cardiac stress response in mice by decreasing histone H3K23 propionylation J Clin Invest.
This study investigates the impact of reducing dietary branched-chain amino acids (BCAA) on cardiac hypertrophy and gene expression in mice subjected to pressure overload. The study found that a BCAA-free diet led to decreased histone H3K23 propionylation, resulting in reduced collagen gene expression, fibrosis, and the progression of cardiac hypertrophy, suggesting that lowering BCAA intake could mitigate the development of cardiomyopathy.
Products Used: EpiQuik Total Histone Extraction Kit
Hysek M et. al. (August 2023). 5hmC Immunohistochemistry: A Predictor of TERT Promoter Mutational Status in Follicular Thyroid Carcinoma? J Histochem Cytochem. 71(8):451-458.
This study explores the use of 5hmC immunohistochemistry to predict TERT promoter mutational status in follicular thyroid tumors. The study found that 5hmC immunohistochemistry is not a sensitive marker for detecting TERT promoter mutations in these tumors, with low sensitivity but high specificity.
Products Used: 5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]
