BackgroundTransmembrane kinase, part of activin receptor complex with type-1 receptors. Transmits activin signals from cell surface, impacting processes like neuronal differentiation, hair follicle development, wound healing, and more. In complex, type-2 receptors bind activin and phosphorylate type-1 receptors. Activated type-1 receptors phosphorylate SMAD proteins, which form a complex that enters the nucleus, mediating activin-induced transcription. Inhibitory SMAD7 and inhibin-B modulate this pathway.
DescriptionACVR2B Recombinant Monoclonal Antibody [7B10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ13705
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Activin Receptor Type IIB
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesActivin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB), ACVR2B
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200
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