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Signal Transduction Antibodies

Signal Transduction Antibodies

Signal transduction, or cell signaling, is the process by which various signals are transmitted throughout the cell in a cascading series of extracellular and intracellular molecular events involving lipids, proteins, and ions. Often it involves a signal from a secreted growth factor, hormone or other extracellular signaling molecule with binding to receptors at the cell surface, including receptor tyrosine kinases and G-protein coupled receptors, which then transduce the signal intracellularly. A wide range of antibodies are involved in signal transduction, such as cell surface receptor and kinase antibodies, intracellular kinase and adaptor protein antibodies, phosphatase antibodies, and secreted growth factor antibodies. Signaling pathways and their fluid dynamic processes can be studied by researchers aiming to learn more about their far-reaching morphological effects and especially their influence on the regulation of gene expression. Signal transduction antibodies can also offer insight into various pathways and their role in the development of diseases, for example, Alzheimer’s, lupus, cancer and rheumatoid arthritis.
Cell Surface Receptor & Kinase Antibodies
Cell surface receptors transduce signals from the exterior of the cell to the interior by binding to secreted or extracellular factors, including hormones, growth factors, neurotransmitters, or other molecules. Cell surface receptors are generally classified by their tertiary structure or their membrane topology. Cell surface receptors include enzyme-linked receptors, G-protein coupled receptors and ion channel-linked receptors. Transduction of the intracellular signal can be mediated by protein-protein interactions by effector proteins, or by enzymatic activity as in the case of the enzyme-linked receptors. The enzyme-linked receptors usually possess enzymatic activity themselves, or associate with kinases or other enzymatic proteins intracellularly.

Intracellular Kinase & Adaptor Protein Antibodies
After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

Phosphatase Antibodies
Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Secreted Growth Factor Antibodies
Growth factors, peptide hormones, neurotransmitters and other secreted molecules initiate diverse signals involved in controlling cellular growth and proliferation, tissue development and differentiation, cellular metabolism and other biological processes. They initiate signals by binding to a receptor on the cell surface, which then undergoes a conformational change leading to an intracellular signaling cascade.

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ANGPTL3 Polyclonal Antibody, FITC Conjugated
ANGPTL3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A64082-05050 µg $256.00 Add to Cart
A64082-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL3 Polyclonal Antibody, HRP Conjugated
ANGPTL3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A64081-05050 µg $256.00 Add to Cart
A64081-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL7 Polyclonal Antibody
ANGPTL7 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A50033-02020 µg $59.00 Add to Cart
A50033-05050 µg $256.00 Add to Cart
A50033-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL7 Polyclonal Antibody, Biotin Conjugated
ANGPTL7 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50036-05050 µg $256.00 Add to Cart
A50036-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL7 Polyclonal Antibody, FITC Conjugated
ANGPTL7 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50035-05050 µg $256.00 Add to Cart
A50035-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL7 Polyclonal Antibody, HRP Conjugated
ANGPTL7 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50034-05050 µg $256.00 Add to Cart
A50034-100100 µg $359.00 Add to Cart
Antibodies
Angptl8 Polyclonal Antibody
Angptl8 Polyclonal Antibody

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Mouse
Trial Size Available: Yes
A55287-02020 µg $59.00 Add to Cart
A55287-05050 µg $256.00 Add to Cart
A55287-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL8 Polyclonal Antibody
ANGPTL8 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A54736-02020 µg $59.00 Add to Cart
A54736-05050 µg $256.00 Add to Cart
A54736-100100 µg $359.00 Add to Cart
Antibodies
Angptl8 Polyclonal Antibody, Biotin Conjugated
Angptl8 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Mouse
A55290-05050 µg $256.00 Add to Cart
A55290-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL8 Polyclonal Antibody, Biotin Conjugated
ANGPTL8 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A54733-05050 µg $256.00 Add to Cart
A54733-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL8 Polyclonal Antibody, FITC Conjugated
ANGPTL8 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A54734-05050 µg $256.00 Add to Cart
A54734-100100 µg $359.00 Add to Cart
Antibodies
Angptl8 Polyclonal Antibody, FITC Conjugated
Angptl8 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Mouse
A55289-05050 µg $256.00 Add to Cart
A55289-100100 µg $359.00 Add to Cart
Antibodies
Angptl8 Polyclonal Antibody, HRP Conjugated
Angptl8 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Mouse
A55288-05050 µg $256.00 Add to Cart
A55288-100100 µg $359.00 Add to Cart
Antibodies
ANGPTL8 Polyclonal Antibody, HRP Conjugated
ANGPTL8 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Growth, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A54735-05050 µg $256.00 Add to Cart
A54735-100100 µg $359.00 Add to Cart
Antibodies
ANK3 Polyclonal Antibody
ANK3 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69875-02020 µg $59.00 Add to Cart
A69875-05050 µg $249.00 Add to Cart
A69875-100100 µg $399.00 Add to Cart
Antibodies
ANK3 Polyclonal Antibody, Biotin Conjugated
ANK3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69878-05050 µg $249.00 Add to Cart
A69878-100100 µg $399.00 Add to Cart
Antibodies
ANK3 Polyclonal Antibody, FITC Conjugated
ANK3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69877-05050 µg $249.00 Add to Cart
A69877-100100 µg $399.00 Add to Cart
Antibodies
ANK3 Polyclonal Antibody, HRP Conjugated
ANK3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69876-05050 µg $249.00 Add to Cart
A69876-100100 µg $399.00 Add to Cart
Antibodies
ANO2 Polyclonal Antibody
ANO2 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A69283-02020 µg $59.00 Add to Cart
A69283-05050 µg $249.00 Add to Cart
A69283-100100 µg $399.00 Add to Cart
Antibodies
ANO2 Polyclonal Antibody, Biotin Conjugated
ANO2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69286-05050 µg $249.00 Add to Cart
A69286-100100 µg $399.00 Add to Cart
Antibodies
Result Pages: [<< Prev]  ... 6  7  8  9  10 ...  [Next >>]  Displaying 101 to 120 (of 2525 products)
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