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Signal Transduction Antibodies

Signal Transduction Antibodies

Signal transduction, or cell signaling, is the process by which various signals are transmitted throughout the cell in a cascading series of extracellular and intracellular molecular events involving lipids, proteins, and ions. Often it involves a signal from a secreted growth factor, hormone or other extracellular signaling molecule with binding to receptors at the cell surface, including receptor tyrosine kinases and G-protein coupled receptors, which then transduce the signal intracellularly. A wide range of antibodies are involved in signal transduction, such as cell surface receptor and kinase antibodies, intracellular kinase and adaptor protein antibodies, phosphatase antibodies, and secreted growth factor antibodies. Signaling pathways and their fluid dynamic processes can be studied by researchers aiming to learn more about their far-reaching morphological effects and especially their influence on the regulation of gene expression. Signal transduction antibodies can also offer insight into various pathways and their role in the development of diseases, for example, Alzheimer’s, lupus, cancer and rheumatoid arthritis.
Cell Surface Receptor & Kinase Antibodies
Cell surface receptors transduce signals from the exterior of the cell to the interior by binding to secreted or extracellular factors, including hormones, growth factors, neurotransmitters, or other molecules. Cell surface receptors are generally classified by their tertiary structure or their membrane topology. Cell surface receptors include enzyme-linked receptors, G-protein coupled receptors and ion channel-linked receptors. Transduction of the intracellular signal can be mediated by protein-protein interactions by effector proteins, or by enzymatic activity as in the case of the enzyme-linked receptors. The enzyme-linked receptors usually possess enzymatic activity themselves, or associate with kinases or other enzymatic proteins intracellularly.

Intracellular Kinase & Adaptor Protein Antibodies
After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

Phosphatase Antibodies
Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Secreted Growth Factor Antibodies
Growth factors, peptide hormones, neurotransmitters and other secreted molecules initiate diverse signals involved in controlling cellular growth and proliferation, tissue development and differentiation, cellular metabolism and other biological processes. They initiate signals by binding to a receptor on the cell surface, which then undergoes a conformational change leading to an intracellular signaling cascade.

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ARL1 Polyclonal Antibody
ARL1 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68459-02020 µg $99.00 Add to Cart
A68459-05050 µg $249.00 Add to Cart
A68459-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, Biotin Conjugated
ARL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68462-05050 µg $249.00 Add to Cart
A68462-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, FITC Conjugated
ARL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68461-05050 µg $249.00 Add to Cart
A68461-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, HRP Conjugated
ARL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68460-05050 µg $249.00 Add to Cart
A68460-100100 µg $399.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody
ARRB1 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A62102-02020 µg $99.00 Add to Cart
A62102-05050 µg $256.00 Add to Cart
A62102-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, Biotin Conjugated
ARRB1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62105-05050 µg $256.00 Add to Cart
A62105-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, FITC Conjugated
ARRB1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62104-05050 µg $256.00 Add to Cart
A62104-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, HRP Conjugated
ARRB1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62103-05050 µg $256.00 Add to Cart
A62103-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody
ARRDC3 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A58174-02020 µg $99.00 Add to Cart
A58174-05050 µg $256.00 Add to Cart
A58174-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, Biotin Conjugated
ARRDC3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58175-05050 µg $256.00 Add to Cart
A58175-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, FITC Conjugated
ARRDC3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58176-05050 µg $256.00 Add to Cart
A58176-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, HRP Conjugated
ARRDC3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58177-05050 µg $256.00 Add to Cart
A58177-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody
ASAP3 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A66542-02020 µg $99.00 Add to Cart
A66542-05050 µg $256.00 Add to Cart
A66542-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, Biotin Conjugated
ASAP3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66545-05050 µg $256.00 Add to Cart
A66545-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, FITC Conjugated
ASAP3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66544-05050 µg $256.00 Add to Cart
A66544-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, HRP Conjugated
ASAP3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66543-05050 µg $256.00 Add to Cart
A66543-100100 µg $359.00 Add to Cart
Antibodies
ASIC2 Polyclonal Antibody
ASIC2 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69851-02020 µg $99.00 Add to Cart
A69851-05050 µg $249.00 Add to Cart
A69851-100100 µg $399.00 Add to Cart
Antibodies
ASIC2 Polyclonal Antibody, Biotin Conjugated
ASIC2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69854-05050 µg $249.00 Add to Cart
A69854-100100 µg $399.00 Add to Cart
Antibodies
ASIC2 Polyclonal Antibody, FITC Conjugated
ASIC2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69853-05050 µg $249.00 Add to Cart
A69853-100100 µg $399.00 Add to Cart
Antibodies
ASIC2 Polyclonal Antibody, HRP Conjugated
ASIC2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69852-05050 µg $249.00 Add to Cart
A69852-100100 µg $399.00 Add to Cart
Antibodies
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