APP Recombinant Monoclonal Antibody [6F10]

Background
Functions as a cell surface receptor on neurons, vital for neurite growth, adhesion, and axonogenesis. Controls protein interactions influencing mobility and transcription. Activates transcription through APBB1-KAT5 and inhibits Notch via Numb binding. Impacts apoptosis, G(O) and JIP pathways. Acts as kinesin I receptor, aiding beta-secretase and presenilin 1 axonal transport. Manages copper homeostasis and oxidative stress. Regulates neurite growth via matrix interactions. Some isoforms inhibit proteases. Triggers AGER-dependent pathway, impacting amyloid-beta and mitochondrial function. Supplies Cu(2+) to GPC1 for nitric oxide and heparan sulfate degradation.

Description
APP Recombinant Monoclonal Antibody [6F10]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human, Mouse, Rat

Isotype
Rabbit IgG

Uniprot ID
P05067

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human Amyloid beta A4

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Amyloid-beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP, Soluble APP-alpha (S-APP-alpha), Soluble APP-beta (S-APP-beta), C99 (Beta-secretase C-terminal fragment) (Beta-CTF), Amyloid-beta protein 42 (Abeta42) (Beta-APP42), Amyloid-beta protein 40 (Abeta40) (Beta-APP40), C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF), P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)), Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)), Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)), C31], APP, A4 AD1

Application
ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200