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Histone Methylation

Histone Methylation

Histone methylation causes transcription repression or activation, depending on the target sites. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. Measurement of histone methyltrasferase activity and quantification of histone methylation patterns have become pivotal in studying epigenetic regulation of genes, as well as inhibitor discovery.
Histone Methylation Quantification
Histone methylation is the modification of certain amino acids in a histone protein by the addition of methyl groups. Methylation and demethylation of histones turn genes on and off in DNA. Quantifying histone methylation is particularly useful for studying gene expression patterns.

Histone Methyltransferase Assay
Histone methyltransferases (HMTs) are enzymes that catalyze the transfer of methyl groups to histone proteins, and control or regulate DNA methylation through chromatin-dependent transcription repression or activation. Histone methylation serves in both epigenetic gene activation and silencing, thereby making it important to measure the activity or inhibition of HMTs.

Histone Demethylase Assay
Histone demethylation is the removal of methyl groups in modified histone proteins via histone demethylases. The discovery of histone demethylases demonstrates that histone methylation is not a permanent modification, but rather a more dynamic process. Specific demethylases are found to be involved in some pathological processes such as cancer progression, making it necessary to better understa...

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EpiQuik Total Histone H4 Quantification Kit (Colorimetric)
EpiQuik Total Histone H4 Quantification Kit (Colorimetric)

Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3072-4848 assays $246.00 Add to Cart
P-3072-9696 assays $462.00 Add to Cart
Research Kits
EpiQuik Total Histone H4 Quantification Kit (Fluorometric)
EpiQuik Total Histone H4 Quantification Kit (Fluorometric)

Citations (1)
Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3073-4848 assays $246.00 Add to Cart
P-3073-9696 Assays $462.00 Add to Cart
Research Kits
EpiQuik Histone Demethylase (H3K4 Specific) Activity/Inhibition Assay Kit
EpiQuik Histone Demethylase (H3K4 Specific) Activity/Inhibition Assay Kit

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3074-4848 assays $338.00 Add to Cart
P-3074-9696 assays $549.00 Add to Cart
Research Kits
EpiQuik Histone Demethylase LSD1 Inhibitor Screening Assay Core Kit
EpiQuik Histone Demethylase LSD1 Inhibitor Screening Assay Core Kit

Citations (1)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3075A-4848 assays $163.00 Add to Cart
P-3075A-9696 assays $318.00 Add to Cart
Research Kits
EpiQuik Histone Demethylase LSD1 Activity/Inhibition Assay Kit
EpiQuik Histone Demethylase LSD1 Activity/Inhibition Assay Kit

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3076-4848 assays $266.00 Add to Cart
P-3076-9696 assays $452.00 Add to Cart
Research Kits
EpiQuik Histone Demethylase (H3K9 Specific) Activity/Inhibition Fast Assay Kit
EpiQuik Histone Demethylase (H3K9 Specific) Activity/Inhibition Fast Assay Kit

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3077-4848 assays $277.00 Add to Cart
P-3077-9696 assays $493.00 Add to Cart
Research Kits
Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Colorimetric)

Citations (1)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3078-4848 assays $338.00 Add to Cart
P-3078-9696 assays $549.00 Add to Cart
Research Kits
Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Fluorometric)
Epigenase LSD1 Demethylase Activity/Inhibition Assay Kit (Fluorometric)

Citations (1) | (1)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3079-4848 assays $338.00 Add to Cart
P-3079-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Colorimetric)

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3080-4848 assays $338.00 Add to Cart
P-3080-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Fluorometric)
Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kit (Fluorometric)

Citations (2)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3081-4848 assays $338.00 Add to Cart
P-3081-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Colorimetric)

Citations (1)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3082-4848 assays $338.00 Add to Cart
P-3082-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Fluorometric)
Epigenase JARID Demethylase Activity/Inhibition Assay Kit (Fluorometric)

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3083-4848 assays $338.00 Add to Cart
P-3083-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Colorimetric)

Citations (4)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3084-4848 assays $338.00 Add to Cart
P-3084-9696 assays $549.00 Add to Cart
Research Kits
Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Fluorometric)
Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Fluorometric)

Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3085-4848 assays $338.00 Add to Cart
P-3085-9696 assays $549.00 Add to Cart
Research Kits
Epigenase PRMT Methyltransferase (Type II-Specific) Activity/Inhibition Assay Kit (Colorimetric)
Epigenase PRMT Methyltransferase (Type II-Specific) Activity/Inhibition Assay Kit (Colorimetric)

Citations (1)
Input Type: Nuclear Extracts, Purified Enzyme
Research Area: Histone Methylation
Target Application: Activity Measurement
Vessel Format: 96-Well Plate
P-3088-4848 assays $338.00 Add to Cart
P-3088-9696 assays $586.00 Add to Cart
Research Kits
EpiQuik Global Di-Methyl Histone H4R3 Quantification Kit (Colorimetric)
EpiQuik Global Di-Methyl Histone H4R3 Quantification Kit (Colorimetric)

Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3090-4848 assays $349.00 Add to Cart
P-3090-9696 assays $596.00 Add to Cart
Research Kits
EpiQuik Circulating Total Histone H3 Quantification Kit (Colorimetric)
EpiQuik Circulating Total Histone H3 Quantification Kit (Colorimetric) new product

Input Type: Plasma or Serum
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3091-4848 assays $256.00 Add to Cart
P-3091-9696 assays $483.00 Add to Cart
Research Kits
EpiQuik Global Di-Methyl Histone H3R8 Quantification Kit (Colorimetric)
EpiQuik Global Di-Methyl Histone H3R8 Quantification Kit (Colorimetric) new product

Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3096-4848 assays $256.00 Add to Cart
P-3096-9696 assays $483.00 Add to Cart
Research Kits
EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric)
EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric)

Citations (3) | (1)
Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3100-9696 assays $699.00 Add to Cart
Research Kits
EpiQuik Histone H4 Modification Multiplex Assay Kit (Colorimetric)
EpiQuik Histone H4 Modification Multiplex Assay Kit (Colorimetric)

Input Type: Histone Extracts
Research Area: Histone Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-3102-9696 assays $599.00 Add to Cart
Research Kits
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