Product Comparison Chart

DNA Bisulfite Modification & Methylation

	Methylamp DNA Modification Kit	Methylamp Coupled DNA Isolation & Modification Kit	Methylamp 96 DNA Modification Kit	Methylamp One-Step DNA Modification Kit	Methylamp Whole Cell Bisulfite Modification Kit	Methylamp Universal Methylated DNA Kit	Methylamp Universal Methylated DNA Preparation Kit
Catalog Number	P-1001	P-1002	P-1008	P-1010	P-1016	P-1011	P-1019
Properties
Input Material	DNA	Cells, tissues, blood	DNA	DNA	Cells, tissues, blood	Methylated DNA	DNA
Lowest amount of Input	50 pg	500 cells/≤ 1 ul blood	100 pg	50 pg	≤ 100 cells/≤ 1 µl blood	100 pg	1 ng
Bisulfite Processing Time	1.5 h	1.5 h	1.5 h	1.5 h	1.5 h	1.5 h
Total Processing Time	≤ 2 h	≤ 2.5 h	≤ 2.5 h	< 2 h	< 3 h	< 2 h	4-16 h
Elution Volume	8-20 µl	8-20 µl	20-40 µl	8-20 µl	8-20 µl	8-20 µl	10-100 µl
Conversion Efficiency	99.9%	99.9%	99.5%	99.5%	99.9%
Desulphonation/clean-up	✓	✓	✓	✓	✓
Bisulfite DNA recovery	>75%	>75%	>75%	>75%	>85%	75%	85%
Format
Single vial	✓	✓		✓	✓	✓	✓
96-well plate			✓
Rapid spin column	✓	✓	✓	✓	✓	✓

Methylated DNA Quantification

	Methylamp Global DNA Methylation Quantification Kit	Methylamp Global DNA Methylation Quantification Ultra Kit	SuperSense Methylated DNA Quantification Kit
Catalog Number	P-1014	P-1014B	P-1021
Properties
Input Material	ssDNA/dsDNA	ssDNA/dsDNA	ssDNA/dsDNA
Maximum Amount of Input	400 ng	200 ng	200 ng
Minimum Amount of Input	100 ng	20 ng	5 ng
Processing Time	4 h	3 h	2.5 h
Detection Limit (Methylated DNA)	1 ng	0.2 ng	0.05 ng
Specificity (meDNA/unDNA Detection Ratio)	> 60:1	> 40:1	> 40:1
Format
Colorimetric	✓	✓
Fluorometric			✓
Strip-well Microplate	✓	✓	✓
Application
Purpose	Methylated DNA quantification. Excellent for relative comparison between samples. Good for measurement of absolute amount in an individual sample.	Methylated DNA quantification. Excellent for relative comparison between samples. Good for measurement of absolute amount in an individual sample.	Methylated DNA quantification. Excellent for relative comparison between samples. Good for measurement of absolute amount in an individual sample.

DNA Methyltransferase

	EpiQuik Dnmt Activity/ Inhibition Assay Kit	EpiQuik Dnmt Activity/ Inhibition Assay Kit (Fluorometric)	EpiQuik Dnmt1 Activity/ Inhibitor Screening Assay Kit	EpiQuik Dnmt3B Activity/ Inhibitor Screening Assay Kit	EpiQuik Dnmt1 Assay Kit	EpiQuik Dnmt3A Assay Kit	EpiQuik Dnmt3B Assay Kit
Catalog Number	P-3001	P-3004	P-3006	P-3007	P-3011	P-3012	P-3013
Properties
Input Material	Nuclear Extract/Purified Enzyme	Nuclear Extract/Purified Enzyme	Purified Enzyme	Purified Enzyme	Nuclear Extract/Purified Enzyme	Nuclear Extract/Purified Enzyme	Nuclear Extract/Purified Enzyme
Amount of Input	5-20 µg/20-200 ng	5-20 µg/5-200 ng	50-100 ng	50-100 ng	2-20 µg/2-100 ng	2-20 µg/2-100 ng	2-20 µg/2-100 ng
Positive Control	✓	✓			✓	✓	✓
Purified Enzyme for Assay			✓	✓
Processing Time	3-4 h	3-4 h	3-4 h	3-4 h	3 h	3 h	3 h
Detection Limit (Purified Dnmt1/3b)	10 ng	2 ng			2 ng	1 ng	2 ng
Format
Colorimetric	✓		✓	✓	✓	✓	✓
Fluorometric		✓
Strip-well Microplate	✓	✓	✓	✓	✓	✓	✓
Application
Purpose	Total Dnmt activity measurement. Also suitable for Dnmt inhibition measurement after in vivo/in vitro treatment with Dnmt inhibitors.	Total Dnmt activity measurement. Also suitable for Dnmt inhibition measurement after in vivo/in vitro treatment with Dnmt inhibitors.	Dnmt1 inhibitor screening.	Dnmt 3b inhibitor screening.	Dnmt1 protein level quantification.	Dnmt 3a protein level quantification.	Dnmt 3b protein level quantification.

DNA Preparation

	FitAmp General Tissue Section DNA Isolation Kit	FitAmp Plasma/Serum DNA Isolation Kit	FitAmp Gel DNA Isolation Kit	FitAmp Paraffin Tissue Section DNA Isolation Kit	DNA Concentrator Kit	FitAmp Urine DNA Isolation Kit	FitAmp Blood and Cultured Cell DNA Extraction Kit
Catalog Number	P-1003	P-1004	P-1007	P-1009	P-1006	P-1017	P-1018
Properties
Input Material	Tissue/Tissue Section	Plasma/Serum	Gel DNA	Paraffin Tissues	DNA	Urine	Blood/Cultured Cells
Maximum DNA Amount/Prep 5 µg	≤ 5 µg	≤ 2 µg	≤ 5 µg	≤ 5 µg	≤ 5 µg	≤ 5 µg	≤ 5 µg
Total Processing Time	≤ 2 h	≤ 15 min	≤ 15 min	< 2 h	≤ 3 min	≤ 30 min	≤ 30 min
Elution Volume	8-20 µl	8-20 µl	20-40 µl	8-20 µl	8-20 µl	8-20 µl	8-20 µl
% DNA Yield	> 70%	> 70%	> 85%	> 70%	> 85%	> 75%	> 75%
Format
Single Vial	✓	✓	✓	✓	✓	✓	✓
Proteinase K	✓	✓		✓		✓	✓
Rapid Spin Column	✓	✓	✓	✓	✓	✓	✓
Application
Purpose	DNA Isolation	DNA Isolation	Gel DNA Isolation	DNA Isolation	DNA Concentrating	DNA Isolation	DNA Isolation
Fresh/Frozen Tissue	✓
FFPE Tissue				✓
Tissue Sections	✓
FFPE Tissue Sections				✓
Cultured Cells							✓
Whole Blood							✓
Buccal Cells/Swabs							✓
Buffy Coat							✓
Urine						✓
Semen						✓	✓
Plasma/Serum		✓

Protein Extraction

	EpiQuik Nuclear Extraction Kit I	EpiQuik Nuclear Extraction Kit II	EpiQuik Whole Cell Extraction Kit	EpiQuik Total Histone Extraction Kit
Catalog Number	OP-0002-1	OP-0002-2	OP-0003-100	OP-0006
Properties
Input Material	Tissue/Cells	Tissue/Cells	Cells	Tissue/Cells
Input Amount	Varied	Varied	Varied	Varied
Total Processing Time	≤ 1 h	≤ 1 h	≤ 45 min	< 1 h
Extracted Proteins	Nuclear Protein	Nucleic Acid-Free	Whole Cell Protein	Histone Protein
Protein Yield	5 µg/10 mg tissue or 1 million cells	5 µg/10 mg tissue or 1 million cells	10 µg/10 mg tissue or 1 million cells	0.4 µg/100 mg tissue or 1 million cells
Nucleic Acid with Protein	Yes	None, or Little	Yes	Yes
Enzyme Activity	Yes	No	Yes	No
Application
Purpose	Enzyme Activity Assay, Protein Detection	Protein Detection	Enzyme Activity Assay, Protein Detection	Histone Detection
Fresh/Frozen Tissue	✓	✓	✓	✓
Cultured Cells	✓	✓	✓	✓
Whole Blood	✓	✓	✓	✓
Buccal Cells/Swabs	✓	✓	✓	✓
Buffy Coat	✓	✓	✓	✓
Urine	✓	✓	✓	✓
Semen	✓	✓	✓	✓

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