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Martínez-Iglesias O et. al. (August 2023). Influence of Metabolic, Transporter, and Pathogenic Genes on Pharmacogenetics and DNA Methylation in Neurological Disorders Biology (Basel). 12(9)
This study investigates the interplay between pharmacogenetics and DNA methylation in neurological disorders. By analyzing serum samples from two patient groups, researchers identify specific genetic variations in drug-metabolizing enzymes, transporter genes, and pathogenic genes that impact drug responses and phenotypic outcomes. These findings underscore the potential for personalized treatment approaches based on genetic and epigenetic factors to improve therapeutic outcomes in brain-related disorders.
Products Used: MethylFlash Methylated DNA Quantification Kit (Fluorometric)
Bergsten E et. al. (December 2023). Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes Gut Microbes. 15(2):2265138.
This study investigates the role of Parvimonas micra, an oral bacterium, in colorectal cancer (CRC). It identifies a specific strain, phylotype A, strongly associated with CRC. Phylotype A alters DNA methylation and gene expression patterns, potentially contributing to cancer development. This research provides insights into the impact of P. micra on CRC.
Products Used: MethylFlash Methylated DNA Quantification Kit (Fluorometric)
Olichwier A et. al. (October 2023). SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes Biochim Biophys Acta Mol Cell Res. :119608.
The article explores the role of Stearoyl-CoA desaturase 1 (SCD1) in regulating lipolysis and epigenetic modifications in the heart. The study demonstrates that SCD1 influences DNA methylation and gene expression in cardiomyocytes. These findings highlight the significance of SCD1 in the heart's epigenetic response to oxygen levels and its role in controlling gene expression.
Products Used: EpiQuik Nuclear Extraction Kit, EpiQuik Total Histone Extraction Kit, EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric), EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric), EpiQuik Histone H4 Modification Multiplex Assay Kit (Colorimetric), EpiQuik Global Histone H4 Acetylation Assay Kit
Lupancu TJ et. al. (October 2023). Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis iScience. 26(10):108079.
This study uncovers how glucocorticoids (GCs), potent anti-inflammatory agents used in rheumatoid arthritis treatment, regulate CCL17 production. GCs suppress CCL17 expression by downregulating JMJD3 activity. In mouse models and RA patient cells, GC treatment reduces CCL17 production, offering new therapeutic possibilities for inflammatory conditions while mitigating GC-associated side effects.
Products Used: Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Ninfali C et. al. (October 2023). The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2 Cell Rep. 42(10):113222.
This study investigates the regulation of human embryonic stem cell differentiation into myogenic cells. It finds that ZEB1 promotes this process, while ZEB2 inhibits it. ZEB1 activates key myogenic genes, and ZEB2 activates neural markers. The findings suggest potential enhancements to stem cell-based therapy for muscular dystrophy by modulating ZEB1 and ZEB2 expression.
Products Used: EpiQuik Chromatin Immunoprecipitation (ChIP) Kit
Liu W et. al. (October 2023). RD29A and RD29B rearrange genetic and epigenetic markers in priming systemic defense responses against drought and salinity Plant Sci. 337:111895.
This study reveals the significance of two drought-responsive genes, RD29A and RD29B, induced by beneficial rhizobacteria. These genes play crucial roles in enhancing plant defense against drought and salinity stress without compromising growth. RD29A and RD29B have distinct functions, with RD29B being essential for salinity tolerance. This research provides insights for engineering stress-tolerant crops.
Products Used: EpiQuik Plant ChIP Kit
Huang T et. al. (December 2023). Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension Epigenetics. 18(1):2242225.
The study examines m6A methylation in idiopathic pulmonary arterial hypertension (IPAH). It finds elevated total m6A levels in the peripheral blood of IPAH patients and identifies specific m6A modifications in genes like RPS27A and SMAD3, suggesting their role in IPAH. Changes in mRNA and protein levels of these genes are observed in human blood samples and experimental models, suggesting the importance of m6A methylation in IPAH.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric), EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
Luo L et. al. (September 2023). Anti-resorption role of low-intensity pulsed ultrasound (LIPUS) during large-scale bone reconstruction using porous titanium alloy scaffolds through inhibiting osteoclast differentiation Biomater Adv. 154:213634.
This study explores how low-intensity pulsed ultrasound (LIPUS) enhances bone regeneration. LIPUS inhibits osteoclast formation, promoting bone growth and maturity, potentially preventing bone resorption. This effect is mediated by reduced RNA m6A modifications via increased FTO expression during osteoclast differentiation.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Huang Y et. al. (December 2023). Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics Phytomedicine. 121:155117.
This study investigates Isovitexin (IVT) as a potential treatment for liver fibrosis. IVT is found to alleviate liver fibrosis by regulating the miR-21-mediated PI3K/Akt signaling and the glutathione metabolic pathway. This research uncovers IVT's capacity to reduce collagen deposition and hepatic stellate cell activation, offering novel insights into liver fibrosis therapy.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Gao X et. al. (October 2023). Low RNA stability signifies strong expression regulatability of tumor suppressors Nucleic Acids Res.
The article explores the relationship between RNA stability and the regulation of tumor suppressor genes and reveals that tumor suppressor genes with low RNA stability exhibit strong expression regulatability. These findings shed light on the potential mechanisms for controlling tumor suppressor gene expression, offering insights into cancer research and therapy development.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Yang W et. al. (October 2023). YTHDF1 mitigates acute kidney injury via safeguarding m6A-methylated mRNAs in stress granules of renal tubules Redox Biol. 67:102921.
This study uncovers the role of YTHDF1 in acute kidney injury (AKI). YTHDF1 safeguards m6A-modified mRNAs within stress granules (SGs) in renal tubules during AKI. Increased YTHDF1 levels in AKI patients and mouse models underscore its protective function. Depleting YTHDF1 reduces mRNA accumulation in SGs, leading to enhanced cell apoptosis under stress. These findings highlight the crucial role of YTHDF1 in AKI, offering insights for potential therapeutic strategies.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Wang F et. al. (October 2023). LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2 J Exp Clin Cancer Res. 42(1):267.
The article investigates how the long non-coding RNA FTO-IT1 influences hepatocellular carcinoma (HCC). FTO-IT1, highly expressed in HCC, promotes cell proliferation and glycolysis, contributing to the disease's progression. It stabilizes FTO mRNA, reducing m6A modifications on glycolysis-related genes, ultimately enhancing HCC. A reciprocal loop is discovered between c-Myc and FTO-IT1, underscoring the potential of FTO-IT1 as a therapeutic target for HCC.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
