BackgroundTET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4. 5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
DescriptionTET1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
SpecificityMouse, Rat, Human
IsotypeIgG
Uniprot IDQ8NFU7
PurificationAffinity Purified
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1800-1900 of human TET1 (NP_085128.2).
StorageShipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Alternative NamesbA119F7.1 antibody, CXXC 6 antibody, CXXC finger 6 antibody, CXXC type zinc finger protein 6 antibody, KIAA1676 antibody, LCX antibody, Leukemia associated protein with a CXXC domain antibody, Methylcytosine dioxygenase TET1 antibody, Ten eleven translocation 1 antibody, Ten eleven translocation 1 gene protein homolog antibody, Tet 1 antibody, Tet methylcytosine dioxygenase 1 antibody, Tet oncogene 1 antibody, TET1 antibody, TET1_HUMAN antdy
ApplicationWB, IHC, IF; Recommended dilution: WB 1:500 - 1:1000; IHC 1:50 - 1:200; IF 1:50 - 1:200
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