DNMT3A Polyclonal Antibody

Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Description
DNMT3A Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3

Specificity
Mouse, Rat, Human

Isotype
IgG

Uniprot ID
Q9Y6K1

Purification
Affinity Purified

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DNMT3A (NP_072046.2)

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
DNA (cytosine 5) methyltransferase 3 alpha antibody, DNA (cytosine-5)-methyltransferase 3A antibody, DNA cytosine methyltransferase 3A2 antibody, DNA methyltransferase 3a antibody, DNA methyltransferase HsaIIIA antibody, DNA MTase HsaI antibody, DNA MTase HsaIIIA antibody, DNM3A_HUMAN antibody, DNMT 3a antibody, DNMT antibody, DNMT3A2 antibody, M HsaIIIA antibody, MCMT antibody, Methyl CpG binding domain protein 3a antibody, OTTHUMP00000201149 antibody, DNMT3A2, M.HsaIIIA

Application
WB, IF; Recommended dilution, WB 1:500 - 1:2000, IF 1:50 - 1:20