Background
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Description
DNMT1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Specificity
Human, Rat

Isotype
IgG

Uniprot ID
P26358

Purification
Affinity Purified

Immunogen
Recombinant Protein of Human DNMT1

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN

Application
WB, IF, IP ; Recommended dilution: WB 1:500 - 1:2000; IF 1:50 - 1:200; IP 1:50 - 1:100

Dery KJ et. al. (May 2018). Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1. J Biol Chem.

Qiao X et. al. (June 2017). 5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats. PLoS One. 12(6):e0179469.