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Du Y et. al. (February 2024). Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry New Phytol.
This study delves into the intricate regulation of flavonoid synthesis in black wolfberry (Lycium ruthenicum Murr.) and its profound impact on bioactivity, with a particular focus on the differences observed among various production regions. The research aims to uncover the genetic and molecular mechanisms underlying the variation in flavonoid content and medicinal properties of black wolfberry, ultimately shedding light on the major quality regulation network governing its bioactivity.
Products Used: EpiQuik Plant ChIP Kit
Cho JH et. al. (February 2024). Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex Autophagy.
In this study, researchers investigated the impact of sodium butyrate (NaB) on high glucose-induced mitophagy dysregulation, neuronal apoptosis, and cognitive impairment in diabetic mice and cell models. They found that NaB restored neuronal mitophagy by recovering PRKN/Parkin-mediated mitophagy and inhibiting the RELA/p65-HDAC8 complex, highlighting its potential as a therapeutic agent for diabetes-associated cognitive impairment.
Products Used: EpiQuik Chromatin Accessibility Assay Kit
Kim YY et. al. (February 2024). KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma Nat Commun. 15(1):1703.
This study investigates the effects of methionine deficiency on B7H3-DAP12-CAR-T cells in the treatment of lung squamous cell carcinoma (LUSC). The researchers found that while B7H3-DAP12-CAR-T cells showed significant killing effects on LUSC cells, the competitive consumption of methionine by LUSC cells led to methionine deficiency, suppressing CAR-T cell function and inducing cell exhaustion. Maintaining methionine levels in CAR-T cells could potentially overcome this suppression and improve their clinical application potential in treating LUSC.
Products Used: EpiQuik Total Histone Extraction Kit, Histone H3K9me2 Dimethyl Peptide
Noel ES et. al. (February 2024). Early life adversity drives sex-dependent changes in 5-mC DNA methylation of parvalbumin cells in the prefrontal cortex in rats bioRxiv.
The study specifically focuses on how ELA, induced by early caregiver deprivation in a rat model, impacts the DNA methylation patterns of parvalbumin (PV) cells in the prefrontal cortex (PFC). PV cells are a type of inhibitory neuron associated with ELA and affective dysfunction. The researchers used maternal separation as a model of ELA to explore sex- and age-specific outcomes on the epigenetic patterning of PV cells in the PFC. They examined 5-methylcytosine (5-mC) DNA methylation, a key epigenetic modification, to understand how early experiences shape later-life behavior, particularly related to anxiety and depression.
Products Used: 5-Methylcytosine (5-mC) Monoclonal Antibody [33D3], MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)
Lim I et. al. (February 2024). Epigenetics in the diagnosis and prognosis of head and neck cancer: A systematic review J Oral Pathol Med. 53(2):90-106.
The article summarizes the current research on epigenetic changes in head and neck squamous cell carcinoma (HNSCC). While some promising epigenetic biomarkers show potential for early detection of HNSCC, the clinical applicability of these findings is limited by the lack of well-designed longitudinal studies and a small number of patients, highlighting the need for further research in this area.
Products Used: EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric)
Wu Q et. al. (February 2024). Circulating tumor cell clustering modulates RNA splicing and polyadenylation to facilitate metastasis Wu Q et. al. (February 2024).
The article investigates the differences in alternative splicing (AS) and alternative polyadenylation (APA) profiles between single circulating tumor cells (CTCs) and CTC clusters. The study identifies key AS events in SRSF6 and APA events in PPP1CA that contribute to the increased malignancy and metastatic potential of CTC clusters, providing new insights into the mechanisms driving CTC cluster metastasis.
Products Used: EpiQuik Total Histone Extraction Kit
Rhodes CT et. al. (February 2024). Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles Front Cell Neurosci. 18:1334244.
This study explores the role of Ezh2 in GABAergic interneuron development in the forebrain. The study shows that loss of Ezh2 leads to changes in interneuron subtypes, reduced interneuron production, and alterations in gene expression, highlighting the importance of Ezh2 in normal development and potential implications for disease.
Products Used: EpiQuik Total Histone Extraction Kit
Nishio T et. al. (February 2024). Epigenetic modification of histone acetylation in the sensorimotor cortex after intracerebral hemorrhage Biomed Res. 45(1):1-11.
The study investigates the effects of intracerebral hemorrhage (ICH) on histone acetylation and gene expression related to neuronal plasticity in the sensorimotor cortices. The study shows that ICH increases histone acetylation and alters gene expression, which may affect post-stroke sensorimotor function, suggesting a role for epigenetic regulation in post-stroke neuroplasticity.
Products Used: EpiQuik Total Histone Extraction Kit
Marto CM et. al. (January 2024). In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation Pharmaceutics. 16(2)
The article explores the potential of reversine-treated mouse gingival fibroblasts (GFs) for use in regenerative dentistry. The study demonstrates that reversine treatment induces significant changes in GFs, including cell metabolism, morphology, and acquisition of stem cell characteristics, making them a potential new source for regenerative procedures. However, reversine also showed toxicity at higher concentrations, highlighting the need for careful dosing and further research into its safety and efficacy.
Products Used: MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)
F De Jesus D et. al. (February 2024). Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Nat Cell Biol.
This study highlights the role of N6-methyladenosine (m6A) in regulating the innate immune response in pancreatic β-cells during the onset of type 1 diabetes (T1D). The study shows that m6A methyltransferase METTL3 levels are dynamically regulated in β-cells, impacting the stability of key innate immune mediators and influencing the progression of T1D. These findings suggest that redox regulation of METTL3 could be a potential therapeutic target for modulating the immune response in T1D.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
