BackgroundHistone H3 along with H2A, H2B and H4 is involved in the structure of chromatin in eukaryotic cells. Histone H3 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications, including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation, occur on the N-terminal tail domains of histone H3, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H3 is primarily acetylated at lysine 9, 14, 18, 23, and can also be acetylated at lysine 56.
DescriptionHistone H3K56ac (Acetyl H3K56) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
SpecificityMouse, Rat, Human, Broad Range
IsotypeIgG
Uniprot IDQ16695
PurificationAffinity Purified
ImmunogenA synthetic acetylated peptide around K56 of human Histone H3 (NP_003520.1)
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.
Alternative NamesH3K56ac antibody, H3K56a antibody
ApplicationWB, IHC, IF, IP, ChIP, ChIP-seq; Recommended dilution: WB 1:500 - 1:1000, IHC 1:50 - 1:200, IF 1:50 - 1:200, IP 1:50 - 1:200, ChIP 1:20 - 1:100, ChIP-seq 1:20 - 1:100
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