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Cobo-Vuilleumier N et. al. (December 2024). LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype Clin Transl Med. 14(12):e70134.
This study investigates the potential of LRH-1/NR5A2 activation to reprogram immune cells in type 1 diabetes (T1D), promoting immune tolerance and improving beta cell survival. The results show that pharmacological activation of LRH-1/NR5A2 in T1D immune cells reduces inflammation, enhances mitochondrial function, and shifts immune cells to a tolerogenic phenotype, offering a promising therapeutic strategy to support beta cell viability and mitigate autoimmune attacks in T1D.
Products Used: EpiQuik Histone H3 Modification Multiplex Assay Kit (Colorimetric), EpiQuik Total Histone Extraction Kit
Rahman MM et. al. (December 2024). Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells Cancer Cell Int. 24(1):422.
This study explores the synergistic effects of phenethyl isothiocyanate (PEITC) and withaferin A (WA) on human breast cancer cells (MCF-7 and MDA-MB-231), targeting multiple epigenetic pathways. The combination of PEITC and WA inhibits cancer hallmarks such as cell proliferation, apoptosis, and tumor formation, while significantly altering DNA methylation and histone acetylation pathways, providing a promising therapeutic strategy for breast cancer treatment.
Products Used: EpiQuik Nuclear Extraction Kit, EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric), EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric)
Li Y et. al. (December 2024). MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) Li Y et. al. (December 2024).
This study examines the role of DNMT1 inhibition in enhancing the activity of memory-like natural killer (CIML NK) cells by promoting autophagy. The results show that DNMT1 knockdown increases CIML NK cell activity and cytokine production, while activating the AMPK/mTOR signaling pathway, offering a potential therapeutic strategy for improving immune responses in acute myeloid leukemia (AML).
Products Used: MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)
Nair AR et. al. (December 2024). Differentially Expressed Genes (DEGs) in Umbelliferone (UMB) Producing Endophytic Fusarium oxysporum (ZzEF8) Following Epigenetic Modification J Basic Microbiol. :e2400582.
This study investigates the impact of epigenetic modification on the production of umbelliferone (UMB) in the endophytic Fusarium oxysporum isolate ZzEF8. By treating ZzEF8 with prednisone, a hypomethylating agent, the study reveals significant transcriptional changes, with 60 upregulated genes linked to secondary metabolite biosynthesis, including key enzymes involved in polyketide and non-ribosomal peptide synthesis. The findings suggest a novel biosynthetic pathway for UMB production, which could aid in scaling up its commercial production.
Products Used: MethylFlash Methylated DNA Quantification Kit (Fluorometric)
Chen HQ et. al. (December 2024). KCNJ15 inhibits chemical-induced lung carcinogenesis and progression through GNB1 mediated Hippo pathway Toxicology. :154034.
This study explores the role of KCNJ15 in lung carcinogenesis induced by polycyclic aromatic hydrocarbons (PAHs). The findings reveal that KCNJ15 expression is suppressed during lung cancer progression due to DNA methylation, and its overexpression inhibits cell growth, invasion, and migration by modulating the Hippo-YAP signaling pathway through its interaction with the G protein subunit GNB1. These results highlight KCNJ15 as a potential tumor suppressor and offer new insights into the epigenetic regulation of lung cancer caused by environmental pollutants.
Products Used: EpiQuik MeDIP Ultra Kit
Lu L et. al. (December 2024). The transcription factors ERF105 and NAC72 regulate expression of a sugar transporter gene and hexose accumulation in grape Plant Cell.
This study examines the regulation of the sugar transporter gene VvSWEET15 in grapevine, which plays a key role in hexose accumulation during berry ripening. The study identifies VvERF105 as a repressor that downregulates VvSWEET15 expression during the pre-véraison stage, while VvNAC72 acts as an activator that promotes its expression and hexose accumulation at post-véraison stages. These findings highlight the critical role of transcriptional balance in regulating sugar transport and accumulation in grapevine.
Products Used: EpiQuik Plant ChIP Kit
Wang M et. al. (December 2024). RBM15-dependent m6A modification mediates progression of non-small cell lung cancer cells Mol Med. 30(1):267.
This study investigates the role of RBM15 in the progression of non-small cell lung cancer (NSCLC) through its mediation of m6A modifications. The research demonstrates that RBM15 upregulates KLF1 and downregulates TRIM13, promoting ANXA8 expression, which facilitates NSCLC cell proliferation, invasion, and migration. These findings suggest that targeting the RBM15-mediated m6A modification pathway could offer new therapeutic strategies for NSCLC treatment.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Wang Y et. al. (December 2024). 3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 Ecotoxicol Environ Saf. 290:117549.
This study explores the reproductive toxicity of 3-acetyldeoxynivalenol (3-ADON) on TM3 Leydig cells, showing that exposure leads to testicular damage and cell pyroptosis. The research reveals that 3-ADON induces METTL3-mediated N6-methyladenosine modification of NLRP3 mRNA, enhancing its stability and expression, which contributes to pyroptosis through NLRP3 activation. These findings highlight the role of METTL3 in regulating Leydig cell dysfunction and provide new insights into the molecular mechanisms of 3-ADON toxicity.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
