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Introduction to Epigenetics
Chromatin & Transcription Antibodies

Chromatin & Transcription Antibodies

Antibodies that target proteins associated with chromatin and transcription such as histone deacetylases (HDACs), histone acetyltransferases (HATs), histone methyltransferases (HMTs), and heterochromatin protein 1 (HP1) are important to understanding the epigenetic regulation of chromatin structure and its function. Chromatin is involved in crucial functions of the cell including division, replication, and gene expression.

structure of chromatin, histones, DNAChromatin remodeling antibodies may assist researchers in investigating several families of chromatin remodelers in eukaryotes, including the SWI/SNF, ISWI, CHD, and INO80 family of chromatin remodelers. These chromatin remodeling families share a conserved ATPase domain for ATP-hydrolysis and DNA binding. Other families have epigenetic reader domains which allow them to bind methylated histones or acetylated histones, for example. Many researchers study chromatin remodeling and protein-DNA interactions with ChIP.

DNA replication & transcription antibodies are useful especially for studying the regulation of gene expression. Transcription factors are proteins that bind to DNA that can alter the expression of certain genes. Transcription factors might also catalyze histone acetylation or histone deacetylation. Certain stimuli during development can lead transcription factors to downregulate or upregulate gene expression at particular times, ensuring proper growth. They are also highly implicated in cancer research as they can act as oncogenes or tumor suppressors.

Cell growth antibodies can be used by epigenetic researchers to investigate transcription factors which activate the expression of certain gene sets related to cell cycle progression and cellular growth. For example, the E2F family of transcription factors controls the progression of the cell cycle by inducing the transcription of genes needed to enter into the cell cycle’s S-phase.

Development & differentiation antibodies offer insight into the process by which an organism develops from a single cell and forms into multiple types of cells, creating various organs and tissues. For example, the HOX genes are an important group of genes that control cellular differentiation during development. They are expressed later in the process of development by tissue stem cells in order to differentiate into their lineages. In addition, embryonic stem cells express transcription factors crucial for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.
Chromatin Remodeling Antibodies
Chromatin remodeling refers to structural changes in chromatin that transform chromatin from a tight condensed conformation to a looser more permissive conformation. This allows access of transcription factors and other gene regulatory proteins to the DNA, leading to gene activation. Such changes are predominantly mediated by histone modifying enzymes, which catalyze the addition or removal of post-translational modifications to histones, and by several multiprotein chromatin remodeling complexes, which can alter nucleosome positioning. Besides its key role in regulating transcription and gene expression, chromatin remodeling is crucial for DNA replication and repair, as well as other cellular processes.

DNA Replication & Transcription Antibodies
DNA replication is the process by which DNA is duplicated or copied prior to cell division, and which allows the daughter cell to retain a set of its own genetic material. During this process, the two DNA strands are unwound by helicases forming replication forks, and DNA is copied by DNA polymerases to form daughter DNA strands. In eukaryotic cells, the nucleosomes at replication forks must be disassembled and then assembled back. DNA replication progresses by duplication of the DNA at several replication origins. DNA replication follows a semiconservative model, where each daughter cell retains an original parental DNA strand and a newly synthesized daughter strand.

Cell Growth Antibodies
Cell growth can refer to an increase in cell number, by proliferation and cell division, or to an increase in the cells volume, without cell division. Growth of a cell population or cell doubling is dependent on cell division, and involves the completion of successive cell cycles. Cell growth in terms of volume, is when the cytoplasm and organelles of a cell increase in volume due to increased transcription and protein synthesis. This occurs during G1 and G2 phases of the cell cycle, in preparation of the cell prior to DNA duplication during S-phase, or prior to cell division into two daughter cells during the mitotic phase.

Development & Differentiation Antibodies
Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

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CALML5 Polyclonal Antibody
CALML5 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51313-02020 µg $59.00 Add to Cart
A51313-05050 µg $256.00 Add to Cart
A51313-100100 µg $359.00 Add to Cart
Antibodies
CALML5 Polyclonal Antibody, Biotin Conjugated
CALML5 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51316-05050 µg $256.00 Add to Cart
A51316-100100 µg $359.00 Add to Cart
Antibodies
CALML5 Polyclonal Antibody, FITC Conjugated
CALML5 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51315-05050 µg $256.00 Add to Cart
A51315-100100 µg $359.00 Add to Cart
Antibodies
CALML5 Polyclonal Antibody, HRP Conjugated
CALML5 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51314-05050 µg $256.00 Add to Cart
A51314-100100 µg $359.00 Add to Cart
Antibodies
CBFB Polyclonal Antibody
CBFB Polyclonal Antibody

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58438-02020 µg $59.00 Add to Cart
A58438-05050 µg $256.00 Add to Cart
A58438-100100 µg $359.00 Add to Cart
Antibodies
CBFB Polyclonal Antibody, Biotin Conjugated
CBFB Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58439-05050 µg $256.00 Add to Cart
A58439-100100 µg $359.00 Add to Cart
Antibodies
CBFB Polyclonal Antibody, FITC Conjugated
CBFB Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58440-05050 µg $256.00 Add to Cart
A58440-100100 µg $359.00 Add to Cart
Antibodies
CBFB Polyclonal Antibody, HRP Conjugated
CBFB Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58441-05050 µg $256.00 Add to Cart
A58441-100100 µg $359.00 Add to Cart
Antibodies
CBX1 Polyclonal Antibody
CBX1 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A-3015-05050 µg $242.00 Discontinued
A-3015-100100 µg $399.00 Discontinued
Antibodies
CBX2 Polyclonal Antibody
CBX2 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A58442-02020 µg $59.00 Add to Cart
A58442-05050 µg $256.00 Add to Cart
A58442-100100 µg $359.00 Add to Cart
Antibodies
CBX2 Polyclonal Antibody, Biotin Conjugated
CBX2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58443-05050 µg $256.00 Add to Cart
A58443-100100 µg $359.00 Add to Cart
Antibodies
CBX2 Polyclonal Antibody, FITC Conjugated
CBX2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58444-05050 µg $256.00 Add to Cart
A58444-100100 µg $359.00 Add to Cart
Antibodies
CBX2 Polyclonal Antibody, HRP Conjugated
CBX2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58445-05050 µg $256.00 Add to Cart
A58445-100100 µg $359.00 Add to Cart
Antibodies
CBX4 Polyclonal Antibody
CBX4 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A-3016-05050 µg $242.00 Add to Cart
A-3016-100100 µg $399.00 Add to Cart
Antibodies
CBX5 Polyclonal Antibody
CBX5 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A50101-02020 µg $59.00 Add to Cart
A50101-05050 µg $256.00 Add to Cart
A50101-100100 µg $359.00 Add to Cart
Antibodies
CBX5 Polyclonal Antibody
CBX5 Polyclonal Antibody

Application: ChIP, IF, IP, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-2701-05050 µl $189.00 Add to Cart
A-2701-100100 µl $299.00 Add to Cart
Antibodies
CBX5 Polyclonal Antibody, Biotin Conjugated
CBX5 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50104-05050 µg $256.00 Add to Cart
A50104-100100 µg $359.00 Add to Cart
Antibodies
CBX5 Polyclonal Antibody, FITC Conjugated
CBX5 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50103-05050 µg $256.00 Add to Cart
A50103-100100 µg $359.00 Add to Cart
Antibodies
CBX5 Polyclonal Antibody, HRP Conjugated
CBX5 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A50102-05050 µg $256.00 Add to Cart
A50102-100100 µg $359.00 Add to Cart
Antibodies
CBX8 Polyclonal Antibody
CBX8 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A-3017-05050 µl $242.00 Add to Cart
A-3017-100100 µl $399.00 Add to Cart
Antibodies
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