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Chromatin & Transcription Antibodies

Chromatin & Transcription Antibodies

Antibodies that target proteins associated with chromatin and transcription such as histone deacetylases (HDACs), histone acetyltransferases (HATs), histone methyltransferases (HMTs), and heterochromatin protein 1 (HP1) are important to understanding the epigenetic regulation of chromatin structure and its function. Chromatin is involved in crucial functions of the cell including division, replication, and gene expression.

structure of chromatin, histones, DNAChromatin remodeling antibodies may assist researchers in investigating several families of chromatin remodelers in eukaryotes, including the SWI/SNF, ISWI, CHD, and INO80 family of chromatin remodelers. These chromatin remodeling families share a conserved ATPase domain for ATP-hydrolysis and DNA binding. Other families have epigenetic reader domains which allow them to bind methylated histones or acetylated histones, for example. Many researchers study chromatin remodeling and protein-DNA interactions with ChIP.

DNA replication & transcription antibodies are useful especially for studying the regulation of gene expression. Transcription factors are proteins that bind to DNA that can alter the expression of certain genes. Transcription factors might also catalyze histone acetylation or histone deacetylation. Certain stimuli during development can lead transcription factors to downregulate or upregulate gene expression at particular times, ensuring proper growth. They are also highly implicated in cancer research as they can act as oncogenes or tumor suppressors.

Cell growth antibodies can be used by epigenetic researchers to investigate transcription factors which activate the expression of certain gene sets related to cell cycle progression and cellular growth. For example, the E2F family of transcription factors controls the progression of the cell cycle by inducing the transcription of genes needed to enter into the cell cycle’s S-phase.

Development & differentiation antibodies offer insight into the process by which an organism develops from a single cell and forms into multiple types of cells, creating various organs and tissues. For example, the HOX genes are an important group of genes that control cellular differentiation during development. They are expressed later in the process of development by tissue stem cells in order to differentiate into their lineages. In addition, embryonic stem cells express transcription factors crucial for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.
Chromatin Remodeling Antibodies
Chromatin remodeling refers to structural changes in chromatin that transform chromatin from a tight condensed conformation to a looser more permissive conformation. This allows access of transcription factors and other gene regulatory proteins to the DNA, leading to gene activation. Such changes are predominantly mediated by histone modifying enzymes, which catalyze the addition or removal of post-translational modifications to histones, and by several multiprotein chromatin remodeling complexes, which can alter nucleosome positioning. Besides its key role in regulating transcription and gene expression, chromatin remodeling is crucial for DNA replication and repair, as well as other cellular processes.

DNA Replication & Transcription Antibodies
DNA replication is the process by which DNA is duplicated or copied prior to cell division, and which allows the daughter cell to retain a set of its own genetic material. During this process, the two DNA strands are unwound by helicases forming replication forks, and DNA is copied by DNA polymerases to form daughter DNA strands. In eukaryotic cells, the nucleosomes at replication forks must be disassembled and then assembled back. DNA replication progresses by duplication of the DNA at several replication origins. DNA replication follows a semiconservative model, where each daughter cell retains an original parental DNA strand and a newly synthesized daughter strand.

Cell Growth Antibodies
Cell growth can refer to an increase in cell number, by proliferation and cell division, or to an increase in the cells volume, without cell division. Growth of a cell population or cell doubling is dependent on cell division, and involves the completion of successive cell cycles. Cell growth in terms of volume, is when the cytoplasm and organelles of a cell increase in volume due to increased transcription and protein synthesis. This occurs during G1 and G2 phases of the cell cycle, in preparation of the cell prior to DNA duplication during S-phase, or prior to cell division into two daughter cells during the mitotic phase.

Development & Differentiation Antibodies
Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

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BHLHE41 Polyclonal Antibody, HRP Conjugated
BHLHE41 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69276-05050 µg $249.00 Add to Cart
A69276-100100 µg $399.00 Add to Cart
Antibodies
BMI1 Polyclonal Antibody
BMI1 Polyclonal Antibody

Application: IF, IHC, IP, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse
A-2739-05050 µl $273.00 Add to Cart
A-2739-100100 µl $465.00 Add to Cart
Antibodies
BMI1 Polyclonal Antibody
BMI1 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A53945-02020 µg $59.00 Add to Cart
A53945-05050 µg $256.00 Add to Cart
A53945-100100 µg $359.00 Add to Cart
Antibodies
BMI1 Polyclonal Antibody, Biotin Conjugated
BMI1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53948-05050 µg $256.00 Add to Cart
A53948-100100 µg $359.00 Add to Cart
Antibodies
BMI1 Polyclonal Antibody, FITC Conjugated
BMI1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53947-05050 µg $256.00 Add to Cart
A53947-100100 µg $359.00 Add to Cart
Antibodies
BMI1 Polyclonal Antibody, HRP Conjugated
BMI1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53946-05050 µg $256.00 Add to Cart
A53946-100100 µg $359.00 Add to Cart
Antibodies
BMPER Polyclonal Antibody
BMPER Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A70079-02020 µg $59.00 Add to Cart
A70079-05050 µg $249.00 Add to Cart
A70079-100100 µg $399.00 Add to Cart
Antibodies
BMPER Polyclonal Antibody, Biotin Conjugated
BMPER Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A70082-05050 µg $249.00 Add to Cart
A70082-100100 µg $399.00 Add to Cart
Antibodies
BMPER Polyclonal Antibody, FITC Conjugated
BMPER Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A70081-05050 µg $249.00 Add to Cart
A70081-100100 µg $399.00 Add to Cart
Antibodies
BMPER Polyclonal Antibody, HRP Conjugated
BMPER Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A70080-05050 µg $249.00 Add to Cart
A70080-100100 µg $399.00 Add to Cart
Antibodies
BRD7 Polyclonal Antibody
BRD7 Polyclonal Antibody

Application: WB
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A-2712-05050 µl $273.00 Add to Cart
Antibodies
BTAF1 Polyclonal Antibody
BTAF1 Polyclonal Antibody

Application: ChIP, IHC, IP, WB
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-2725-05050 µl $189.00 Add to Cart
A-2725-100100 µl $299.00 Add to Cart
Antibodies
BTF3 Polyclonal Antibody
BTF3 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51857-02020 µg $59.00 Add to Cart
A51857-05050 µg $256.00 Add to Cart
A51857-100100 µg $359.00 Add to Cart
Antibodies
BTF3 Polyclonal Antibody, Biotin Conjugated
BTF3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51860-05050 µg $256.00 Add to Cart
A51860-100100 µg $359.00 Add to Cart
Antibodies
BTF3 Polyclonal Antibody, FITC Conjugated
BTF3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51859-05050 µg $256.00 Add to Cart
A51859-100100 µg $359.00 Add to Cart
Antibodies
BTF3 Polyclonal Antibody, HRP Conjugated
BTF3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51858-05050 µg $256.00 Add to Cart
A51858-100100 µg $359.00 Add to Cart
Antibodies
CALML4 Polyclonal Antibody
CALML4 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51077-02020 µg $59.00 Add to Cart
A51077-05050 µg $256.00 Add to Cart
A51077-100100 µg $359.00 Add to Cart
Antibodies
CALML4 Polyclonal Antibody, Biotin Conjugated
CALML4 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51080-05050 µg $256.00 Add to Cart
A51080-100100 µg $359.00 Add to Cart
Antibodies
CALML4 Polyclonal Antibody, FITC Conjugated
CALML4 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51079-05050 µg $256.00 Add to Cart
A51079-100100 µg $359.00 Add to Cart
Antibodies
CALML4 Polyclonal Antibody, HRP Conjugated
CALML4 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51078-05050 µg $256.00 Add to Cart
A51078-100100 µg $359.00 Add to Cart
Antibodies
Result Pages: [<< Prev]  ... 6  7  8  9  10 ...  [Next >>]  Displaying 121 to 140 (of 2267 products)
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