BackgroundNeurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
DescriptionNeurofilament L Monoclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP07196
PurificationAffinity Purified
ImmunogenRecombinant protein (or fragment). Please contact EpigenTek for more information.
StorageStore at -20°C. Avoid freeze / thaw cycles.
Alternative NamesNFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; Neurofilament L
ApplicationWB, IF-P, IHC-P, ELISA; Recommended dilution: WB, 1:10000 - 1:400000; IF-P, 1:200 - 1:800; IHC-P, 1:500 - 1:5000; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
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