Histone H4K16ac (Acetyl H4K16) Polyclonal Antibody

Background
Histone H4- along with H2A, H2B, and H3- is involved in the structure of chromatin in eukaryotic cells. Histone H4 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occur on the N-terminal tail domains of histone H4, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H4 is primarily acetylated at lysine 5, 8, 12, and 16. 

Concentration
0.2 mg/ml

Description
Goat polyclonal antibody raised against a synthetic peptide corresponding to N-terminus of histone H4 acetylated at K16

Purification
Protein A purified

Specificity
Detects histone H4 only when acetylated at K16 in mouse, rat, and human.

Isotype
IgG

Formulation
PBS (pH 7.5), 0.1% gelatin

Storage
4°C, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance

Alternative Names
H4K16ac antibody, H4K16a antibody

Application
WB: 1:200-1:1000, IF: 1:100-1:500, IHC: 1:100-1:500, ELISA: 1:1000-1:2000, IP: 2 μg/10^6 cells