BackgroundGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.
DescriptionGNAI3 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Rat
IsotypeIgG
Uniprot IDP08754
PurificationAffinity Purification
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1-100 of human GNAI3 (NP_006487.1).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesGNAI3; 87U6; ARCND1; G protein subunit alpha i3
ApplicationWB, IHC; Recommended dilution: WB: 1:1000-1:2000, IHC: 1:50-1:100