Cart (0)
Kang YY et. al. (January 2024). Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury Adv Sci (Weinh). :e2308978.
In this study, researchers investigated the impact of systemic innate immune training on tissue protection against local injury. By using β-glucan, an agonist for trained immunity, they observed a reduction in mortality and fibrosis in mice with bleomycin-induced lung injury, highlighting the potential of centrally trained immunity to safeguard peripheral organs from injury-mediated disorders.
Products Used: ChromaFlash High-Sensitivity ChIP Kit
Qin Y et. al. (January 2024). Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: Oxidative stress, apoptosis, and histone hypoacetylation Sci Total Environ. :170521.
The article explores how ceratin benzodiazepines impact adult zebrafish exposed to environmentally relevant concentrations for 30 days. The findings reveal anxiety-like behavior, brain damage, increased apoptosis, higher levels of oxidative stress, and reduced histone acetylation, shedding light on the neurotoxic effects and molecular mechanisms of these drugs in aquatic environments.
Products Used: EpiQuik Global Histone H3 Acetylation Assay Kit, EpiQuik Global Histone H4 Acetylation Assay Kit
Wang J et. al. (January 2024). Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer Cell Death Dis. 15(1):97.
The study investigates the role of UNC-51-like kinase 1 (ULK1) in epithelial ovarian cancer (EOC) and reveals that ULK1 expression is elevated in EOC tissues, correlating with poor prognosis. The research demonstrates that ULK1 is a target of m6A modification by WTAP, and this modification, facilitated by IGF2BP3, enhances ULK1 expression, mitophagy, and contributes to the progression of EOC.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric), EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
Jackson BL et. al. (January 2024). Investigating the Effects of Valproic acid on Placental Epigenetic Modifications and Development in the CD-1 Mouse Model Reprod Toxicol. :108551.
The study explores the impact of maternal exposure to valproic acid (VPA) on mouse placenta and fetal development on gestational day (GD) 13. The findings reveal that VPA exposure at this critical time reduces placental weight, increases fetal resorptions, and induces epigenetic modifications, including elevated histone acetylation and decreased global DNA methylation in placental tissue.
Products Used: MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)
Li Z et. al. (January 2024). Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model Nat Commun. 15(1):831.
In this article, researchers engineered a transposon-associated TnpB-ωRNA system, leveraging the small size of TnpB for efficient mammalian genome editing. The optimized TnpB-ωRNA system, delivered via a single adeno-associated virus (AAV), demonstrated successful in vivo correction of a disease phenotype in a tyrosinaemia mouse model, showcasing its potential as a compact and effective tool for genome editing.
Products Used: CRISPR/Cas9 Monoclonal Antibody [7A9]
Kim B et. al. (January 2024). Pharmacokinetics, pharmacodynamics and safety of oral formulation (CG-750) of ivaltinostat, a histone deacetylase inhibitor, compared to IV formulation (CG-745) Br J Clin Pharmacol.
The study evaluated the pharmacokinetics, pharmacodynamics, and safety of the oral formulation (CG-750) of ivaltinostat, a histone deacetylase (HDAC) inhibitor, in comparison to the intravenous (IV) formulation (CG-745). The results demonstrated that CG-750 was generally well-tolerated with a mean bioavailability of 10.6%, exhibiting linear pharmacokinetics in the dose range of 125-750 mg.
Products Used: EpiQuik Total Histone Extraction Kit
Maestri S et. al. (January 2024). Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing Brief Bioinform. 25(2)
The study developed NanOlympicsMod, a Nextflow pipeline utilizing containerized technology, to benchmark and compare 14 tools for N6-methyladenosine (m6A) detection on Nanopore direct RNA sequencing data. The pipeline demonstrated variable performance across datasets and highlighted the impact of sequencing depth on the precision and recall of m6A detection tools, providing a valuable resource for evaluating and improving RNA modification characterization in the future.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Tian Y et. al. (January 2024). Identification of m6A-Related Biomarkers in Systemic Lupus Erythematosus: A Bioinformation-Based Analysis J Inflamm Res. 17:507-526.
The study identified twelve N6-methyladenosine (m6A) regulatory genes as potential biomarkers for Systemic Lupus Erythematosus (SLE). The analysis highlighted hub genes, including MMP9, which exhibited a causal link to an increased risk of ischemic stroke, a common complication of SLE, offering insights for presymptomatic diagnostic approaches.
Products Used: EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
