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Liu Z et. al. (November 2023). DNA methylation on C5-Cytosine and N6-Adenine in the Bursaphelenchus xylophilus genome BMC Genomics. 24(1):671.
This study explores the epigenetic modifications in the genome of the pinewood nematode (PWN), the causal agent of pine wilt disease. The research reveals the extensive presence of 5-methylcytosine (5mC) and N6-methyladenine (6mA) in the PWN genome, highlighting their potential roles in the nematode's rapid adaptation during invasion, with methylation levels showing temperature and development-dependent patterns.
Products Used: MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)
Chen H et. al. (November 2023). Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans Environ Sci Technol.
In this article, researchers investigate the transgenerational reproductive toxicity of polystyrene nanoplastics (PS-NPs), particularly photoaged PS-NPs, in Caenorhabditis elegans. Exposure to aged PS-NPs results in more severe reproductive effects across multiple generations, with increased levels of H3K4 and H3K9 methylation observed, suggesting a potential mechanism involving the spr-5, met-2, and set-17 genes in the regulation of transgenerational toxicity.
Products Used: EpiQuik Total Histone Extraction Kit, EpiQuik Global Histone H3K4 Methylation Assay Kit, EpiQuik Global Histone H3K9 Methylation Assay Kit
Finnegan E et. al. (November 2023). Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer Cell Oncol (Dordr).
In this study, researchers designed a novel belinostat prodrug, copper-bis-belinostat (Cubisbel), to address the poor metabolic stability of belinostat in colon cancer. Cubisbel showed enhanced metabolic stability, leading to significant reductions in colon cancer cell growth through HDAC inhibition and apoptosis induction, suggesting a promising approach to improve the efficacy of HDACis in colon cancer treatment.
Products Used: EpiQuik Nuclear Extraction Kit
Peng X et. al. (November 2023). Geniposide alleviated hydrogen peroxide-induced apoptosis of human hepatocytes via altering DNA methylation Food Chem Toxicol. :114158.
This article investigates the effects of Geniposide (GP) on hydrogen peroxide (H2O2)-induced apoptosis in human hepatocytes. At a concentration of 900 μg/mL, GP influenced global DNA methylation, increased DNMT1, decreased TET1 and TET2 expression, and inhibited apoptosis by regulating the methylation levels of P53, Bcl-2, and AKT promoter regions, providing valuable insights for its safety evaluation.
Products Used: EpiQuik Nuclear Extraction Kit
Finnegan E et. al. (November 2023). Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer Cell Oncol (Dordr).
This study explores the potential of a novel belinostat prodrug, copper-bis-belinostat (Cubisbel), designed to address the limited therapeutic impact of the histone deacetylase inhibitor (HDACi) belinostat in solid tumors like colon cancer, primarily due to poor metabolic stability. Through in vitro and ex vivo evaluations, Cubisbel demonstrated significant efficacy by reducing colon cancer cell growth, highlighting its potential as a promising strategy to enhance the effectiveness of HDACis in treating colon cancer patients.
Products Used: Epigenase HDAC Activity/Inhibition Direct Assay Kit (Colorimetric)
Qiao Z et. al. (November 2023). SHMT2 regulates esophageal cancer cell progression and immune Escape by mediating m6A modification of c-myc Cell Biosci. 13(1):203.
This study delves into the role of serine hydroxymethyltransferase 2 (SHMT2) in esophageal cancer (EC), revealing its aberrant upregulation in EC and association with poor prognosis. By demonstrating that SHMT2 regulates the malignant progression and immune escape of EC cells through m6A modification of c-myc, the study provides valuable insights into the potential therapeutic targeting of SHMT2 for EC treatment.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Liu Z et. al. (November 2023). DNA methylation on C5-Cytosine and N6-Adenine in the Bursaphelenchus xylophilus genome BMC Genomics. 24(1):671.
This article investigates the pinewood nematode (PWN), the causative agent of pine wilt disease, and explores its rapid adaptations during invasion, focusing on DNA methylation. The research reveals the extensive presence of 5-methylcytosine (5mC) and N6-methyladenine (6mA) in the Bursaphelenchus xylophilus genome, providing insights into the functional DNA modifications that contribute to the PWN's invasiveness and evolution.
Products Used: MethylFlash m6A DNA Methylation ELISA Kit (Colorimetric)
