Background Polycomb group (PcG) proteins form the multiprotein complexes that are important for the transcriptional repression of various genes involved in development and cell proliferation. RING1 is a PcG protein that contains the RING finger motif, a specific zinc-binding domain that is found in many regulatory proteins. It has been shown that RING1 interacts with transcription factor CP2 (TFCP2/CP2) and suppress the activity of CP2. Also, there is involvement of the gene RING1B in the specification of the anterior-posterior axis as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitinconjugating enzyme, as well as possess ubiquitin ligase activity.
ConcentrationInquire
DescriptionRING1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationpH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDQ06587
PurificationAffinity Purified
ImmunogenPeptide sequence around aa.35~39( I-A-V-S-P) derived from Human Ring1A.
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesRing1A antibody, E3 ubiquitin-protein ligase RING1 antibody, Polycomb complex protein RING1 antibody, RING finger protein 1 antibody, Rnf1 antibody, Transcription repressor Ring1A antibody
ApplicationELISA,WB; Recommended dilution: WB:1:500-1:1000
VCU0006