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Phospho Histone H2AX (S139) Monoclonal Antibody [RMC097A]

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Western Blot
Positive WB detected in: 293 whole cell lysate
All lanes: Phospho Histone H2AX (S139) Monoclonal Antibody [RMC097A] at 0.23 ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 KDa
Observed band size: 15 KDa
Application: ELISA, WB
Areas of Research: Histone Phosphorylation & Dephosphorylation
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
100% Guarantee: 6 months
Catalog No.SizePriceQty
A68410-05050 µlView
A68410-100100 µlView
Product Overview

Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Description
Phospho Histone H2AX (S139) Monoclonal Antibody, clone RMC097A. Unconjugated. Raised in: Rabbit.

Concentration
Inquire

Formulation
Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
IgG

Uniprot ID
P16104

Purification
Affinity Purified

Immunogen
A synthesized peptide

Storage
Shipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX

Application
ELISA, WB; Recommended dilution: WB: 1:3000-1:10000

VCU0006

User Guide & MSDS

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