MuERVL-Gag Polyclonal Antibody

Background
When the zygotic genome is first transcribed, a large number of retrotransposons are expressed, including the endogenous retroviruses (ERVs), LINE-1 elements, and the non-autonomous SINE elements. MuERV-L/MERVL retrovirus-like particles are transiently de-repressed and produce 3% of the transcribed mRNAs at the two-cell (2C) stage. Right after the 2C stage, the expression of MERVL-retroelement is silenced. It has been found that this regulated pattern of MERVL expression overlapped with more than one hundred 2C-specific genes that have co-opted regulatory elements from these foreign retroviruses to begin their transcription.  

Description
Rabbit polyclonal antibody to MuERVL Gag.

Formulation
1x PBS, pH 7.3; 50% glycerol; 0.03% ProClin 300

Specificity
Mouse

Isotype
IgG

Immunogen
Synthetic peptide within C-terminal residues of Gag

Protein Length
581 aa (1746 bp gene size)

Uniprot
V9H130

NCBI Accession Number
CAA73250.1

Purification
Affinity purified

Storage
Store at 4°C after thawing. Aliquot store at -20°C (short term) or -80°C (long term). Avoid repeated freeze / thaw cycles.

Alternative Names
Murine Endogenous Retrovirus-Gag, MERVL-Gag

Application
DB, IF, ICC; Recommended dilutions: DB (1:500-1:1000), IF (1:100 - 1:500), ICC (1:100-1:200)