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Introduction to Epigenetics

Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.
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ARRDC3 Polyclonal Antibody
ARRDC3 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A58174-02020 µg $59.00 Add to Cart
A58174-05050 µg $256.00 Add to Cart
A58174-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, Biotin Conjugated
ARRDC3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58175-05050 µg $256.00 Add to Cart
A58175-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, FITC Conjugated
ARRDC3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58176-05050 µg $256.00 Add to Cart
A58176-100100 µg $359.00 Add to Cart
Antibodies
ARRDC3 Polyclonal Antibody, HRP Conjugated
ARRDC3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58177-05050 µg $256.00 Add to Cart
A58177-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody
ASAP3 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A66542-02020 µg $59.00 Add to Cart
A66542-05050 µg $256.00 Add to Cart
A66542-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, Biotin Conjugated
ASAP3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66545-05050 µg $256.00 Add to Cart
A66545-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, FITC Conjugated
ASAP3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66544-05050 µg $256.00 Add to Cart
A66544-100100 µg $359.00 Add to Cart
Antibodies
ASAP3 Polyclonal Antibody, HRP Conjugated
ASAP3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66543-05050 µg $256.00 Add to Cart
A66543-100100 µg $359.00 Add to Cart
Antibodies
BEX1 Polyclonal Antibody
BEX1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Cycle, Cell Development & Differentiation, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A67210-02020 µg $59.00 Add to Cart
A67210-05050 µg $256.00 Add to Cart
A67210-100100 µg $359.00 Add to Cart
Antibodies
BEX1 Polyclonal Antibody, Biotin Conjugated
BEX1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Cycle, Cell Development & Differentiation, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67213-05050 µg $256.00 Add to Cart
A67213-100100 µg $359.00 Add to Cart
Antibodies
BEX1 Polyclonal Antibody, FITC Conjugated
BEX1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Cycle, Cell Development & Differentiation, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67212-05050 µg $256.00 Add to Cart
A67212-100100 µg $359.00 Add to Cart
Antibodies
BEX1 Polyclonal Antibody, HRP Conjugated
BEX1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Cycle, Cell Development & Differentiation, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67211-05050 µg $256.00 Add to Cart
A67211-100100 µg $359.00 Add to Cart
Antibodies
BEX2 Polyclonal Antibody
BEX2 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Apoptosis & Cell Death, Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58258-02020 µg $59.00 Add to Cart
A58258-05050 µg $256.00 Add to Cart
A58258-100100 µg $359.00 Add to Cart
Antibodies
BEX2 Polyclonal Antibody, Biotin Conjugated
BEX2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58259-05050 µg $256.00 Add to Cart
A58259-100100 µg $359.00 Add to Cart
Antibodies
BEX2 Polyclonal Antibody, FITC Conjugated
BEX2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58260-05050 µg $256.00 Add to Cart
A58260-100100 µg $359.00 Add to Cart
Antibodies
BEX2 Polyclonal Antibody, HRP Conjugated
BEX2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Cycle, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58261-05050 µg $256.00 Add to Cart
A58261-100100 µg $359.00 Add to Cart
Antibodies
BRAP Polyclonal Antibody
BRAP Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A69979-02020 µg $59.00 Add to Cart
A69979-05050 µg $249.00 Add to Cart
A69979-100100 µg $399.00 Add to Cart
Antibodies
BRAP Polyclonal Antibody, Biotin Conjugated
BRAP Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69982-05050 µg $249.00 Add to Cart
A69982-100100 µg $399.00 Add to Cart
Antibodies
BRAP Polyclonal Antibody, FITC Conjugated
BRAP Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69981-05050 µg $249.00 Add to Cart
A69981-100100 µg $399.00 Add to Cart
Antibodies
BRAP Polyclonal Antibody, HRP Conjugated
BRAP Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69980-05050 µg $249.00 Add to Cart
A69980-100100 µg $399.00 Add to Cart
Antibodies
Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 81 to 100 (of 998 products)
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