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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.
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ARHGAP25 Polyclonal Antibody
ARHGAP25 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58122-02020 µg $59.00 Add to Cart
A58122-05050 µg $256.00 Add to Cart
A58122-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP25 Polyclonal Antibody, Biotin Conjugated
ARHGAP25 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58123-05050 µg $256.00 Add to Cart
A58123-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP25 Polyclonal Antibody, FITC Conjugated
ARHGAP25 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58124-05050 µg $256.00 Add to Cart
A58124-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP25 Polyclonal Antibody, HRP Conjugated
ARHGAP25 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58125-05050 µg $256.00 Add to Cart
A58125-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP27 Polyclonal Antibody
ARHGAP27 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A65402-02020 µg $59.00 Add to Cart
A65402-05050 µg $256.00 Add to Cart
A65402-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP27 Polyclonal Antibody, Biotin Conjugated
ARHGAP27 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65405-05050 µg $256.00 Add to Cart
A65405-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP27 Polyclonal Antibody, FITC Conjugated
ARHGAP27 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65404-05050 µg $256.00 Add to Cart
A65404-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP27 Polyclonal Antibody, HRP Conjugated
ARHGAP27 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65403-05050 µg $256.00 Add to Cart
A65403-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP29 Polyclonal Antibody
ARHGAP29 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58126-02020 µg $59.00 Add to Cart
A58126-05050 µg $256.00 Add to Cart
A58126-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP29 Polyclonal Antibody, Biotin Conjugated
ARHGAP29 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58127-05050 µg $256.00 Add to Cart
A58127-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP29 Polyclonal Antibody, FITC Conjugated
ARHGAP29 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58128-05050 µg $256.00 Add to Cart
A58128-100100 µg $359.00 Add to Cart
Antibodies
ARHGAP29 Polyclonal Antibody, HRP Conjugated
ARHGAP29 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58129-05050 µg $256.00 Add to Cart
A58129-100100 µg $359.00 Add to Cart
Antibodies
ARHGDIA Polyclonal Antibody
ARHGDIA Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A52636-02020 µg $59.00 Add to Cart
A52636-05050 µg $256.00 Add to Cart
A52636-100100 µg $359.00 Add to Cart
Antibodies
ARHGDIA Polyclonal Antibody, Biotin Conjugated
ARHGDIA Polyclonal Antibody, Biotin Conjugated

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A52633-05050 µg $256.00 Add to Cart
A52633-100100 µg $359.00 Add to Cart
Antibodies
ARHGDIA Polyclonal Antibody, FITC Conjugated
ARHGDIA Polyclonal Antibody, FITC Conjugated

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A52634-05050 µg $256.00 Add to Cart
A52634-100100 µg $359.00 Add to Cart
Antibodies
ARHGDIA Polyclonal Antibody, HRP Conjugated
ARHGDIA Polyclonal Antibody, HRP Conjugated

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A52635-05050 µg $256.00 Add to Cart
A52635-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody
ARHGEF18 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A63334-02020 µg $59.00 Add to Cart
A63334-05050 µg $256.00 Add to Cart
A63334-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody
ARHGEF18 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51713-02020 µg $59.00 Add to Cart
A51713-05050 µg $256.00 Add to Cart
A51713-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody, Biotin Conjugated
ARHGEF18 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51716-05050 µg $256.00 Add to Cart
A51716-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody, Biotin Conjugated
ARHGEF18 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A63337-05050 µg $256.00 Add to Cart
A63337-100100 µg $359.00 Add to Cart
Antibodies
Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 41 to 60 (of 998 products)
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