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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.
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CAB39L Polyclonal Antibody
CAB39L Polyclonal Antibody

Application: ELISA, IF, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58414-02020 µg $59.00 Add to Cart
A58414-05050 µg $256.00 Add to Cart
A58414-100100 µg $359.00 Add to Cart
Antibodies
CAB39L Polyclonal Antibody, Biotin Conjugated
CAB39L Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58415-05050 µg $256.00 Add to Cart
A58415-100100 µg $359.00 Add to Cart
Antibodies
CAB39L Polyclonal Antibody, FITC Conjugated
CAB39L Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58416-05050 µg $256.00 Add to Cart
A58416-100100 µg $359.00 Add to Cart
Antibodies
CAB39L Polyclonal Antibody, HRP Conjugated
CAB39L Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58417-05050 µg $256.00 Add to Cart
A58417-100100 µg $359.00 Add to Cart
Antibodies
CABP5 Polyclonal Antibody
CABP5 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A67294-02020 µg $59.00 Add to Cart
A67294-05050 µg $256.00 Add to Cart
A67294-100100 µg $359.00 Add to Cart
Antibodies
CABP5 Polyclonal Antibody, Biotin Conjugated
CABP5 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67297-05050 µg $256.00 Add to Cart
A67297-100100 µg $359.00 Add to Cart
Antibodies
CABP5 Polyclonal Antibody, FITC Conjugated
CABP5 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67296-05050 µg $256.00 Add to Cart
A67296-100100 µg $359.00 Add to Cart
Antibodies
CABP5 Polyclonal Antibody, HRP Conjugated
CABP5 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67295-05050 µg $256.00 Add to Cart
A67295-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody
CALM1 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A55511-02020 µg $59.00 Add to Cart
A55511-05050 µg $256.00 Add to Cart
A55511-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody
CALM1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51453-02020 µg $59.00 Add to Cart
A51453-05050 µg $256.00 Add to Cart
A51453-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody
CALM1 Polyclonal Antibody

Application: ELISA, IF
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58418-02020 µg $59.00 Add to Cart
A58418-05050 µg $256.00 Add to Cart
A58418-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody
CALM1 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A55759-02020 µg $59.00 Add to Cart
A55759-05050 µg $256.00 Add to Cart
A55759-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, Biotin Conjugated
CALM1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51456-05050 µg $256.00 Add to Cart
A51456-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, Biotin Conjugated
CALM1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A55761-05050 µg $256.00 Add to Cart
A55761-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, Biotin Conjugated
CALM1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58419-05050 µg $256.00 Add to Cart
A58419-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, Biotin Conjugated
CALM1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A55514-05050 µg $256.00 Add to Cart
A55514-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, FITC Conjugated
CALM1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58420-05050 µg $256.00 Add to Cart
A58420-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, FITC Conjugated
CALM1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51455-05050 µg $256.00 Add to Cart
A51455-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, FITC Conjugated
CALM1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A55762-05050 µg $256.00 Add to Cart
A55762-100100 µg $359.00 Add to Cart
Antibodies
CALM1 Polyclonal Antibody, FITC Conjugated
CALM1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A55513-05050 µg $256.00 Add to Cart
A55513-100100 µg $359.00 Add to Cart
Antibodies
Result Pages: [<< Prev]  ... 6  7  8  9  10 ...  [Next >>]  Displaying 101 to 120 (of 998 products)
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